Cellular mediators

Question 1

Cytokines

Answer 1

• Responsible for activating cells and regulating inflammatory response.
• Produces Interkeukin-1 (a pyrogen that causes fever).

Question 2

Chemokines

Answer 2

• Type of cytokine. They attract leukocytes to the site of inflammation.
• Synthesized by many cells (macrophages, fibroblasts, endothelial) in response to proinflammatory cytokines.
• Attract monocyte/macrophage chemotactic proteins, macrophage inflammatory proteins, and neutrophils.
• Promotes phagocytosis and wound healing.