Suppositories

Question 1

Estrogen and prostaglandin

Answer 1

Work best as systemic drugs than as oral drugs

Question 2

Fatty bases

Answer 2

Company butter, adeps solids

Question 3

Water bases

Answer 3

Macrogols and glycero gelatin

Question 4

Cocoa butter

Answer 4

Tri gyceride , yellowish white in colour ,brittle, and smells like chocolate

Question 5

Cocoa butter

Answer 5

At temp. Of 15°C to 25°C, it is a hard amorphous solid, but at 30° to 35°C it melts to a bland

Question 6

Cocoa butter

Answer 6

Low water absorptive ability but can be increased by adding surfactants as cholesterol 2% emulsifying wax up to 10% polysorbate 5 to 10% or wool fat 5 to 10%

Question 7

Synthetic bases

Answer 7

Unaffected by heating.

Question 8

Synthetic bases

Answer 8

Fluid than cocoa butter when melted: hence, drug sedimentation is great

Question 9

Glycerol gelatin

Answer 9

Mixture of water and glycerol made stiff by adding gelatin

Question 10

Glycerol gelatin

Answer 10

Good for suppositories

Question 11

Glycerol gelatin

Answer 11

Suppositories must be kept in a well closed container in a cool dry place since they can absorb and dissolve in atmospheric moisture

Question 12

Glycero gelatin

Answer 12

Suppositions must be dipped in water just before use to facilitate administration

Question 13

Glycero gelatin

Answer 13

Maybe used medicated or unmedicated

Question 14

Gylcero gelatin

Answer 14

Usually denser than theobroma; hence, a correction factor of 1.2 must be accounted for

Question 15

Gylcero gelatin

Answer 15

Glycerine =20%
Drug= 20%
Gelatin = 60%

Question 16

Macrogols ( polyethylene glycol)

Answer 16

Ethylene oxide + water

Question 17

Macrogols

Answer 17

Hardness increases with an increase in molecular weight

Question 18

Macrogols

Answer 18

Drug release is dependent on base dissolving than melting

Question 19

Macrogols

Answer 19

Can provide sustained effect

Question 20

Preparation if suppositories

Answer 20

1. Hand rolling and shaping
2. Fusion molding
3. Compression

Question 21

Compression moulding of suppositories

Answer 21

1.Good for suppositories containing insoluble solids or thermolabile AP1
2.Cannot be used for glycero gelatin products
3. Cannot be uses if melting is an essential part of preparation

Question 22

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