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TIRED YEAR > AP Bimex > Flashcards

AP Bimex Flashcards

1
Q

The methods of extraction, storage, and handling of nucleic acid molecules, depends on the type of the tissue from where they were extracted . *

TRUE
FALSE

A

FALSE

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2
Q

The following are techniques for detecting drugs in serum, except: *

Hemagglutination inhibition immunoassay
Microparticle enzyme immunoassay (Tacrolimus)
Fluorescence polarization immunoassay
High performance liquid chromatography
Thin-layer chromatography

A

Microparticle enzyme immunoassay (Tacrolimus)

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3
Q

In virus, the main enzyme responsible for synthesizing a double helix complementary DNA strand (cDNA) from RNA is___: *

integrase
RNA polymerase
ribonuclease H
reverse transcriptase

A

reverse transcriptase

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4
Q

To ensure documentation of the identification of the tested individuals & the collection of evidences, the following are the CORRECT steps EXCEPT : *

samples individually packaged, sealed, and stored
appropriate informed consent
record of hematopoietic stem cell transplant.
history of any recent transfusion in the preceding month
documents showing the chain of custody of samples

A

history of any recent transfusion in the preceding month

In THE PRECEEDMG 3 MONTHS•

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5
Q

Molecular Techniques are used in the medical field for the following purpose EXCEPT: *

detecting abnormal genes in patient specimens
germline genetic modification
establishing patterns of gene expression that are characteristic of specific diseases
diagnosis of different types of cancers

A

germline genetic modification

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6
Q

This/ These is/ are TRUE of Immunosuppressives: *

used to suppress both the humoral and cell-mediated immune systems.
Corticosteroids are the drugs of choice for use in maintenance of kidney and liver allografts because of their accessibility
Many are antibiotics like rapamycin and mycophenolate mofetil.
Tacrolimus is the drug of choice in organ transplantation because of the absence of potential toxicities
1st & 3rd choices only
2nd & 4th choices only
All of the above

A

1st & 3rd choices only

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7
Q

TRUE of Control swabs Except÷: *

packaged separately, and clearly labelled collected one item at a time
collected from an unstained area
collected adjacent to the fluid stain
collected to either convict or free the accused

A

collected to either convict or free the accused

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8
Q

Acute poisoning may be caused by which of the following? *

Lead
Arsenic
carbon monoxide
Cyanide
Iron

A

Cyanide

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9
Q

antigenic stimuli for activating the cellular response comes from the following areas of the cell , except: *

cytosolic
endosomal
extracellular
mitochondrial

A

mitochondrial

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10
Q

WhichstatementiscorrectregardingSputumcollectionforacidfastbacilli 1point testing? *

sputum specimen must be collected on three consecutive days.
each sputum smear on from each collection day must become positive
collect only once if first smear is positive for AFB.
1st & 3rd choices only
All of the above

A

sputum specimen must be collected on three consecutive days

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11
Q

’- grade squamous intraepithelial lesions (HSIL) comprise of the following findings: *
Koilocytosis & Cervical Intraepithelial Neoplasia (CIN 1)
(Cervical Intraepithelial Neoplasia) CIN 2 & CIN 3
Invasive Carcinoma
1st & 2nd choices only
All of the above

A

(Cervical Intraepithelial Neoplasia) CIN 2 & CIN 3

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12
Q

An allele present in the child:but not in the mother is referred to as the ___. *

obligatory paternal gene (OG)
direct exclusion gene
obligatory paternal allele
1st & 3rd choices only
All of the above

A

1st & 3rd choices only

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13
Q

The simplest of the cells / tissue sampling techniques: *

Surgical biopsy
Abrasive cytology
Exfoliative cytology
Core needle biopsy
Aspiration cytology

A

Exfoliative cytology

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14
Q

DNA in the pathology laboratory can be used to *

resolve specimen mix-ups
confirm or refute mislabeling of biopsy specimens
resolved alleged sample switching
evaluate engraftment of marrow after transplantation
1st & 2nd choices only
3rd & 4th choices only
All of the above

A

All of the above

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15
Q

For CD4+ T-lymphocytes to be activated, the antigen presenting cells displays the antigen via this complex receptor. *

Major histocompatibility complex receptor class II
Major histocompatibility comlex receptor class I
Fc region/receptor
Fab region

A

Major histocompatibility complex receptor class II

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16
Q

. This/These is/are TRUE of chromatographic tests, except : *

In Enzyme-mediated immunologic technique (EMIT),the drug is covalently attached to an enzyme and separated in a high resistance flow column.
Capillary electrophoresis is one example
Gas Chromatography-Mass Spectroscopy is the gold-standard for detection and quantitation of volatile compounds.
Applied mainly to the qualitative detection of drugs of abuse and toxins

A

In Enzyme-mediated immunologic technique (EMIT),the drug is covalently attached to an enzyme and separated in a high resistance flow column.

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17
Q

Immunoglobulin that can cross the placenta and provides the fetus with passive immunity *

IgG
IgA
IgM
IgD

A

IgG

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18
Q

Lead in blood: *

Is measured in serum and plasma
Absorption may occur by inhalation or ingestion
Both organic and inorganic compounds may be highly toxic.
Most serious effects occur in the CNS and peripheral nervous system.
1st, 2nd, & 3rd choices only
2nd, 3rd, & 4th choices only
1st, 3rd, & 4th choices only
All of the above

A

2nd, 3rd, & 4th choices only

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19
Q

Immunoglobulin that can cross the placenta and provides the fetus with passive immunity *

IgG
IgA
IgM
IgD

A

IgG

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20
Q

Routine blood group used for investigations in cases of disputed parentage EXCEPT: *

Duffy
Lewis
HLA
Rh
ABO

A

Lewis

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21
Q

The major cause of simultaneous elevation of prothrombin time & activated 1 point partial thromboplastin time is _______. *
Coumadin therapy
Combined Heparin & Coumadin therapy Heparin therapy
Disseminated intravascular coagulation
Coagulation Factor Deficiency

A

Disseminated intravascular coagulation

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22
Q

Chorionicvillussampling(CVS),whichprovidestissuefromthedeveloping 1point placenta is obtained by the transabdominal or transvaginal procedure,
performed at _______ gestation. *

18 – 22 weeks
14 to 18 weeks
10 to 14 weeks
22-26 weeks

A

10 to 14 weeks

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23
Q

helper T-cells (subset type 2) ? *

IFN-y
IL-5
IL-17
IL-4

A

IL-4

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24
Q

The following statements are true of Anti-asthmatics, except : *

Theophylline is used for prevention of attacks and treatment of symptomatic
exacerbations.
The basic mechanisms of these drugs result in relaxation of smooth muscle relaxation in the small airways
Oral anti-inflammatory agents interrupt the leukotriene/ arachidonic acid pathways involved in inflammation and bronchial reactivitiy
Subcutaneous injection of epinephrine relieves bronchoconstriction in acute asthma attacks.
No exception.

A

No exception.

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25
Q

cells can be cultivated and made to undergo more than twice but a limited number of divisions before senescence by adding cytokines and lectins to the growth media. *

fibroblasts
Lymphocytes
Neutrophils
nasal epithelial cells gastrointestinal mucosal cells

A

Lymphocytes

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26
Q

Regarding Amphetamines : *

Effectively detected by Thin layer chromatography and Enzyme-mediated
immunologic technique .
Best specimen for detection by chromatography is urine.
They bear close resemblance to epinephrine and norepinephrine and maybe expected to exert sympathomimetic effects
May be confused with some antihistamines in routine testing.
All are correct

A

All are correct

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27
Q

What is the maximum but adequate amount of amniotic fluid can a physician withdraw without endangering the fetus:

20 to
30-50 mL
20 to 30 mL
5 -10 mL

A

20 to 30 mL

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28
Q

Which findings would be diagnostic of massive muscle tissue necrosis? *

Creatine kinase (CK)
Potassium
Myoglobin

A

Creatine kinase (CK) - INCREASED
Potassium- INCREASED
Myoglobin- INCREASED

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29
Q

Diagnose: Low 24 hrs urine sodium, normal urine osmolality, high serum sodium urine sodium *

SIADH
Adrenal failure
Diuretics effect
Cushing’s disease

A

Cushing’s disease

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30
Q

What determines the nomenclature of an immunoglobulin? *
the isotype of the light chain t
he Fc region
the secretory component
the isotype of the heavy chain

A

the isotype of the heavy chain

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31
Q

How are cytosines connected to guanines? *

3 hydrogen bonds
25 hydrogen bonds
10 hydrogen bonds
2 hydrogen bonds

A

3 hydrogen bonds

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32
Q

Advantages of DNA Testing EXCEPT: *

DNA testing can only be performed on fresh specimens
Human or primate-specific
DNA is resistant to strong acids, alkalis, detergents, and environmental factors. allows for individualization of the source of the semen

A

DNA testing can only be performed on fresh specimens

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33
Q

Amniocentesis can be typically done during this period of gestation: *

between 14 and16 weeks
between 16 and18 weeks
between 20 - 28 weeks
between 18-20 weeks

A

between 16 and18 weeks

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34
Q

Effects of carbon monoxide intoxication on the body : * 1 point

binds avidly to iron causing inactivation of iron containing enzymes in redox reactions.
blocks the synthesis of tetrahydrofolic acid resulting in blockage of DNA synthesis.
produces tissue hypoxia as a result of decreased oxygen transport
accumulates in soft tissues and bone in chronic toxicity.
inhibits a variety of phosphodiesterases, thereby causing bronchoconstriction and apnea.

A

produces tissue hypoxia as a result of decreased oxygen transport

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35
Q

Interpret: Normal T4&TSH, no mass lesion *

Normal
Euthyroid
Either A or B
None of the above

A

Either A or B

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36
Q

of basic techniques/methods for detecting drugs in serum and urine,
except: *

In Thin-layer chromatography, compounds are separated based on their relative affinities for a polar solid stationary phase.
Nonvolatile compounds can be detected using Liquid chromatography-Mass spectroscopy.
In HPLC, The internal standard is similar in structure to the drug/s of interest and added in a known concentration, and the percentage of recovery from the column is extrapolated for all drugs of interest.
In EMIT and FPIA, the drug serum concentration and the color resulting from the enzymatic reaction and decrease in fluorescence polarization is nonlinear.
In both chromatographic techniques and homogeneous methods, the drug must bind to antibody before it is detected.

A

In both chromatographic techniques and homogeneous methods, the drug must bind to antibody before it is detected.

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37
Q

Reasons for difficulty of obtaining reference ranges for antidepressants are: *

Most are metabolized using the cytochrome P450 system and different antidepressants require different isoforms of cytochrome P450
large numbers of metabolites that vary significantly in concentration in individuals.
Most are lipophilic and therefore stored in tissue and slowly released
High volumes of distribution of these drugs.
all are correct

A

all are correct

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38
Q

The following statements are CORRECT regarding Mitochondrial DNA EXCEPT: *

hundreds to to thousands of copies per cell
small-sized
useful for identifying remains.
inherited from both parents

A

inherited from both parents

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39
Q

The usual blood gas picture in a patient with diabetes mellitus.

Metabolic alkalosis
Metabolic acidosis
Respiratory acidosis
Respiratory alkalosis

A

Metabolic acidosis

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40
Q

A phase of clinically evaluating a suspected patient with immunodeficiency which correlates medical history and family history with complete blood counts and isohemagglutinin titers. *

screening stage
analytic immune stage
confirmatory stage
none of these 3 choices

A

screening stage

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41
Q

the immunoglobulin whose Fc region binds to receptors of phagocytic cells 1 point (i.e. macrophages) *

IgM
IgE
IgA
IgG

A

IgG

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42
Q

Interpret: Normal AST, Normal ALT, Low total protein, low albumin, high ammonia *

Primary adrenalism
Cirrhosis
Fulminant failure
Metabolic acidosis

A

Cirrhosis

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43
Q

Itisthemostprimitiveofalltheimmunoglobulinsandprimarilyconfinedto the intravascular space. *

IgE
IgG
IgA
IgM

A

IgM

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44
Q

Drugs used in the treatment of clinical depression include: *

Selective serotonin Reuptake inhibitors
trazodone and doxepin
Monoamine oxidase inhibitors
lithium
Tricyclic antidepressants

A

lithium

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45
Q

It is the process of comparing a current laboratory result with results obtained on a previous specimen from the same patient. *

critical values
delta checks
reference ranges
linearity ranges
pretest and posttest probability 1st, 3rd, & 5th choices only
2nd & 4th choices only All of the above
1 point

A

delta checks

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46
Q

Absence of an expected genetic marker in a child when the parent in question appears to be homozygous (one allele present) for the gene: *

two-haplotype exclusion
indirect exclusion
reverse homozygosity
1st & 2nd choices only
2nd & 3rd choices only
All of the above

A

2nd & 3rd choices only

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47
Q

involves examination of spontaneously sledded cells from lining of an organ into a cavity

A

Exfoliative cytology

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48
Q

examination of cells collected or removed by brushing or artificial mechanical desquamation

A

Abrasive cytology

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49
Q

a procedure in which a thin needle is inserted into a swelling to collect a sample of cells or some amount of fluid

A

Aspiration cytology

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50
Q

a percutaneous procedure that involves removing a piece of tissue from a lesion or mass, using a hollow needle

A

Core needle biopsy

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51
Q

cutting a sample of the suspicious tissue from a mass for purposes of Diagnosis

A

Surgical biopsy

52
Q

Among the bodytissues, this is /these are the most stable source/s of postmortem tissue DNA: *

Bone
liver
brain
teeth
1st & 4th choices only
2nd & 3rd choices only
all of the above

A

1st & 4th choices only

53
Q

These can destroy the stability of DNA: *

detergents
gasoline
metal ions
Ultraviolet radiation
3rd & 4th choices only
1st & 2nd choices only
All of the above

A

3rd & 4th choices only

54
Q

The following are true of environmental toxins: *

Acquired hemochromatosis is caused by overingestion of iron.
The most common drug of abuse is ethanol.
Organophosphates contained in pesticides interfere with neurotransmission by inhibiting the enzyme acetylcholinesterase (AChE).
Arsenic is used in rodenticides, herbicides, insecticides, ceramics, production of livestock feed and medicines.
1st & 3rd choices only
2nd & 4th choices only
All of the above

A

All of the above

55
Q

To preserve the DNA, this specimen should be transported in ice:

amniotic fluid
Chorionic villi
Blood
Solid tissue
Bine marrow

A

Solid tissue

56
Q

A test with a higher sensitivity _______ a greater proportion of persons ______ disease. *

identifies – without
excludes - with
excludes - without
identifies – with

A

identifies – with

57
Q

A frequent cause of inadequate samples is the presence of high concentrations of interfering substances in the specimen such as in the following conditions: *

Lipemia
Hemolysis
Gammopathies Icterus
1st, & 3rd choices only
2nd & 4th choices only
All of the above

A

All of the above

58
Q

The laboratory test that determines the presence of markers of immunoglobulins synthesized in the central nervous system due to an autoimmune disease or an immunologic response to an infection. *

Immunoglobulin free light chain analysis
Cryoglobulin testing
Immunofixation electrophoresis
Oligoclonal immunoglobulim band testing

A

Oligoclonal immunoglobulin band testing

59
Q

Type of cytological technique:

Voided urine

A

Exfoliative cytology

60
Q

Type of cytological technique:

Breast tumor

A

Abrasive cytology

61
Q

Type of cytological technique:

Buccal mucosal smear

A

Abrasive cytology

62
Q

Type of cytological technique:

Thyroid nodule

A

Aspration cytology

63
Q

Corticosteroids are : *

highly effective anti-inflammatory agents
effective in blocking inflammation by similar mechanisms as Nonsteroidal anti- inflammatory drugs.
used to treat congenital hyperbilirubinemia as it enhances the metabolism of bilirubin by induction of cytochrome P450- dependent enzymes.
Side effects are fluid retention, osteoporosis, GI bleeding, mental changes
1st, 2nd, & 4th choices only
2nd, 3rd, & 4th choices only
1st, 3rd, & 4th choices only
All of the above

A

1st, 2nd, & 4th choices only

64
Q

In Transcription, the anti-sense strand is the__. *

template strand & non-coding strand
non-template strand & coding strand
non-template strand & non-coding strand
template strand & coding strand

A

Non-template strand and coding strand

65
Q

In the documentation of panic values, the following information should be written & recorded except: *

name of patient
title or position of the caregiver who is notified
the time and date of notification
the read-back by the health care worker
critical value
name of caregiver
All except 1st & 5th choices
All except 2nd & 6th choices
No exception

A

No exception

66
Q

the best studied immunoglobulin isotype and possess a high diffusion coefficient. *

IgM
IgE
IgA
IgG

A

IgG

67
Q

In progenitor stem cell transplantation what comes out in the result. *

the DNA of recipient’s parents
the donor’s DNA
the recipient’s DNA

A

the donor’s DNA

68
Q

Factors That Influence Reference Ranges: *

time between specimen collection and specimen endorsement

A

pre-analytical factor variation with physician as
specimen collector

69
Q

Factors That Influence Reference Ranges: *

sample transport

A

pre-analytical factor variation with physician as
specimen collector

70
Q

time between receipt of specimen and analysis

A

Analyst laboratory factor

71
Q

type of laboratory methods

A

analyst & laboratory factor

72
Q

exposure to environmental factors

A

Analyst and laboratory factors

73
Q

The presence of these cells confirm the specimen as “sputum” rather than “mere saliva”. *

flat squamous cells
foamy macrophages
columnar ciliated cells
neutrophils
2nd & 3rd choices only
All of the above

A

2nd & 3rd choices only

74
Q

TRUE of neuroleptics and antipsychotic major tranquilizers : *
Difficult to monitor the levels in serum because of the large number of metabolites of
each drug.
Reference ranges for serum levels have not been established.
used mainly in the treatment of acute schizophrenia
Block the actions of dopamine and serotonin postsynaptically in the limbic system and motor cortex
All of the above are correct.

A

All of the above are correct.

75
Q

Pap smear is recommended every 1-2 years for the following: *

women between ages 18 - 70 years
women who have ever had sexual contact women of any age who are sexually active
1st & 2nd choices only
All of the above

A

1st & 2nd choices only

76
Q

The principle behind this instrument is to categorize cells based on their size and nuclear complexity. It is primarily used to classify different types of leukemia. *

Flow Cytometry
Microlymphocytotoxicity by dye exclusion
Enzyme-lnked immunosorbent spot assay
Protein electrophoresis

A

Flow cytometry

77
Q

Confirmatory tests require ______ to be certain of the diagnosis. *

low sensitivity
high sensitivity
low specificity
high specificity

A

high specificity

78
Q

The four areas of study in Toxicology include the following, except: *

detection of toxins the individual is exposed to
determination of levels of therapeutic drugs administered to patients
detection of mutated proteins and abnormal DNA sequences
detection of drugs of abuse
no exception

A

no exception

79
Q

These are laboratory results that may represent a life-threatening situation that may not otherwise be readily detectable. *

critical values
delta checks
reference ranges
linearity ranges
pretest and posttest probability
1st, 3rd, & 5th choices only
2nd & 4th choices only
All of the above

A

critical values

80
Q

It is the predominant antibody in secretions *

IgD
IgA
IgG
IgM

A

IgA

81
Q

A double swab techniqueis the preferred method for collection of DNA in the following condition: *

biologic fluid deposited on a surface
dry biologic fluid
from bitemarks on bodies
from large pools of blood and bloodstains.

A

from bitemarks on bodies

82
Q

The immunoglobulin that initiate aspects of the allergic reaction and binds to basophils via the Fc region. *

IgG
IgE
IgA
IgM

A

IgE

83
Q

A phase of clinically evaluating a suspected patient with immunodeficiency which utilizes thymic MRI imaging and skin testing *

screening stage
none of these 3 choices
confirmatory stage
analytic immune stage

A

confirmatory stage

84
Q

Monitoring of therapeutic drugs is essential because of the following reasons: *

Possible toxic side effects of medications
Lack of patient compliance resulting in subtherapeutic levels that may require intervention.
To achieve a constant serum level that will be therapeutic
Therapeutic efficacy of metabolites of some therapeutic drugs are unknown.
1st & 3rd choices only
2nd & 4th choices only
All of the above

A

All of the above

85
Q

Diagnose: high 24hr urine sodium, low urine osmolality, low serum sodium *

Diabetes insipidus
Bartter’s syndrome
SIADH
Dehydration

A

Bartter’s syndrome

86
Q

When do you put the smears &/or tissue in the fixative solution? *

right after slide smearing or as soon as tissue is collected immediately after air drying the cytology smears
instantly after the surgical biopsy wound is sutured
as soon as the physician gets the opportunity
2nd & 3rd choices only
All of the above

A

right after slide smearing or as soon as tissue is collected

87
Q

Infection with this organism can result to squamous koilocytotic atypia, dysplasias, & eventually to carcinoma when untreated. *

Monilia
Gardnerella vaginalis
Human Papillomavirus
Trichomonas vaginalis
Herpes Simplex

A

Human Papillomavirus

88
Q

zone wherein antigen and antibodies are approximately of equal molar concentration and where the largest antibody-antigen complexes occur/formed. *

zone of equivalence
zone of proportionality
zone of antibody equity
zone of disequivalence

A

zone of equivalence

89
Q

Phenobarbital as an anticonvulsant, possess this/these following characteristics, except : *

neuronal membrane stabilizer through intercalation
given for withdrawal symptoms in infants born to opiate or barbiturate-addicted mothers.
Induce a number of the cytochrome P450 systems
Diminishes frequency of firing action potentials by potentiating the gamma- aminobutyric acid (GABA) effect
no exception

A

no exception

90
Q

antigenic substances can be composed of : *

large polysaccharides
proteins
glycoproteins
all of these 3 choices

A

all of these 3 choices

91
Q

The following drugs slow down the electrical conduction in the heart by their effects on the action potentials in myocytes and conduction system. *

Lidocaine block rapid sodium influx in phase 1
Betablockers like propranolol increases the intrasarcolemmal concentration of calcium
Amiodarone inhibits the chronotropic effects of adrenergic neurotransmitters.
Class IV drugs like Verapamil increasethe length of the refractory period by blocking the repolarizing potassium currents
all of the above are correct

A

Lidocaine block rapid sodium influx in phase 1

92
Q

Interpret: Elevated TSH, Normal RDW *

Primary hyperthyroidism
Primary adrenalism
Hypothyroidism
Euthyroid

A

Hypothyroidism

93
Q

Aspiration biopsy procedure is not indicated for: *

the spleen
patients with bleeding disorders
patient at risk for bleeding from chemo-radiation or from cancer itself
patient taking blood thinning drugs.
Last 3 choice only
All of the above

A

All of the above

94
Q

The mechanisms of action of the cardiotropics in slowing down electrical 1 point conduction include: *

block sodium influx in phase I of the action potential
increase length of the action potential by blocking repolarizing potassium currents
inhibit the chronotropic effects of epinephrine and norepinephrine
increase the length or refractory period by slowing the influx of calcium ions
1st & 3rd choices only
2nd & 4th choices only
All of the above

A

All of the above

95
Q

MOLECULAR TESTS for Disease Detection *

Cytokines in inflammation

A

Macroarrays

96
Q

MOLECULAR TESTS for Disease Detection *

M tuberculosis

A

Hybridization line-blot reverse

97
Q

MOLECULAR TESTS for Disease Detection *

Gene expression profiling & DNA sequencing

A

Microarrays oligonucleotide

98
Q

MOLECULAR TESTS for Disease Detection *

CMV

A

ASSAYS CAPTURE HYBRID

99
Q

The use of fixatives, such as alcohol, formalin, or a mixture of both is indicated in all types of cells / tissue sampling techniques. *

False
True in all techniques
Fresh specimens may not be soaked in fixatives True in biopsy techniques only
True in cytology techniques only

A

True in all techniques

100
Q

True statements of sedative-hypnotics, except: . *

Cannabis (marijuana), smoked or ingested orally is readily stored in the body fat and
maybe detected in the urine 1-4 wks from ingestion.
The sedative-hypnotic effects of barbiturates is due to the selective inhibition of the reticular activating system.
Cocaine is the oldest and most widely used of the mind-altering drugs.
Methaqualone is a local anesthetic that possess anticonvulsant and antitussive properties.
All of the barbiturates are fat-soluble and pass easily across the blood-brain barrier.

A

Cocaine is the oldest and most widely used of the mind-altering drugs.

101
Q

MOLECULAR TESTING FOR DISEASES *

Clostridium difficile; group A and Group B beta hemolytic streptococci; Mycoplasma pneumoniae;

A

LOOP-MEDIATED AMPLIFICATION (LAMP)

102
Q

HPV; thrombophilia mutations (Factor II, Factor V)

A

CLEAVASE/INVADER TECHNOLOGY

103
Q

Neisseria gonorrhoeae, Chlamydia trachomatis, Human papillomavirus (HPV);Trichomonas vaginalis,

A

TRANSCRIPTION- BASED AMPLIFICATION

104
Q

influenza RNA; A and B viruses

A

NICKING ENZYME AMPLIFICATION REACTION (NEAR)

105
Q

The primary medicinal use of Opiates is: *

local anesthesia
antitussive
tranquilizers
sedative-hypnotics
analgesic/ to diminish or eliminate pain in a patient.

A

analgesic/ to diminish or eliminate pain in a patient.

106
Q

Osler’s rule

For patient under the age of 60 years, try to attribute all abnormal laboratory findings to a single cause.
Never rely on a single out-of-reference range value to make a diagnosis.
Only if there is no possible way to correlate all abnormal findings should the possibility of multiple diagnoses be entertained.
1st & 3rd choices only
1st & 2nd choices only
All of the above

A

1st & 3rd choices only

107
Q

A jaundiced patient with all high serum enzymes & bilirubin, but normal protein, is most likely to have _____. *

Hemolytic anemia
Inflamed liver
Obstructed cystic duct
Hepatoma

A

Inflamed liver

108
Q

The following are examples of toxins, except : *

Cyanide
Ethanol
Mercury
Lithium
Iron

A

Lithium

109
Q

True of neuroleptics and antipsychotic major tranquilizers :

Difficult to monitor the levels in serum because of the large number of metabolites of each drug.
Reference ranges for serum levels have not been established.
used mainly in the treatment of acute schizophrenia
Block the actions of dopamine and serotonin postsynaptically in the limbic system and motorcortex
1st, 2nd, & 4th choices only
2nd, 3rd, & 4th choices only
1st, 3rd, & 4th choices only
All of the above

A

All of the above

110
Q

This test for COVID-19 virus needs a respiratory specimen:

PCR testing
Antigen Testing Antibody testing
1st & 2nd choices only
2nd & 3rd choices only
All of the above

A

1st & 2nd choices only

111
Q

The first and most critical step for evidence: *

recording hematopoietic stem cell transplant.
extraction of DNA from biologic sources
requesting informed consent
documenting the chain of custody of samples
noting recent transfusion in the preceding month

A

extraction of DNA from biologic sources

112
Q

The micronutrient essential for thymic development and is severely deficient in malnourished patients. *

zinc
vitamin C
selenium
iron

A

Zinc

113
Q

A patient complaining of dizziness has the following Lab results below. Microcytic Normocytic erythrocytes; Normal serum iron /total Iron binding capacity ratio; Decreased red cell count; Normal iron binding capacity; Decreased serum iron; Normal red cell distribution width; High ferritin. What is the most probable diagnosis? *

Megaloblastic Anemia
Aplastic Anemia
Anemia of Chronic Disease
Hemolytic Anemia
Renal Failure
Iron Deficiency Anemia

A

Anemia of Chronic Disease

114
Q

the criminalistics context, DNA can be used: *

to link or exculpate a suspect to a crime,
to recognize serial crimes
to aid in accident reconstruction identification of human remains
1st & 2nd choices only
3rd & 4th choices only
All of the above

A

All of the above

115
Q

Immunoglobulin that can exist as a dimer *

IgD
IgG
IgA
IgM

A

IgA

116
Q

The postanalytic evaluation process, on the clinical significance of the Laboratory Test result, includes the following: *

critical values
delta checks
reference ranges
linearity ranges
pretest and posttest probability
1st, 3rd, & 5th choices only
2nd & 4th choices only All of the above

A

1st, 3rd, & 5th choices only

117
Q

This is NOT TRUE regarding using DNA as an identity marker: *

the same throughout life from the time of conception
the same in all cells of the body except the gametocytes different in all individuals including identical twins
present throughout all the nucleated cells of the body

A

different in all individuals including identical twins

118
Q

The most important site for Gynaecological Cytology sampling: *

exocervical-vaginal junction
endocervical – exocervical junction
endometrial- endocervical junction
tubal-endometrial junction

A

endocervical – exocervical junction

119
Q

At what part of the antibody do antigens react/bind to? *

Disulfide bonds
Fab region
Fc region
secretory component

A

Fab region

120
Q

The fundamental characteristics of TARGET AMPLIFICATION METHODS EXCEPT: *

All produce millions to billions of copies of the targeted sequence in a matter of hours
The primers bind to complementary sequences on one strand of double-stranded targets.
The amplification products in all the techniques are defined by two oligonucleotide primers.
They are enzyme-mediated processes that synthesize copies of target nucleic acid.

A

The primers bind to complementary sequences on one strand of double-stranded targets.

121
Q

Which findings would be diagnostic of disseminated intravascular coagulopathy (DIC) in a patient with fulminant liver failure?

apTT
platelet counts
partial thromboplastin time (PTT)
D-dimer

A

apTT - INCREASED
platelet count- DECREASED
partial thromboplastin time (PTT) - INCREASED
D-dimer- INCREASED

122
Q

Given the correct culture conditions, these cells can divide and grow in vitro for 50-100 generations. *

Lymphocytes
fibroblasts
gastrointestinal mucosal cells
nasal epithelial cells
Neutrophils

A

fibroblasts

123
Q

These are true as to the following anti-inflammatory drugs:

Aspirin is a steroidal compound that is an analgesic and antipyretic.
Acetaminophen is preferred over Aspirin as toxicity never occur.
Nonsteroidal anti-inflammatory agents block cyclooxygenase.
Acetylsalicylic acid (Aspirin) exhibits anticoagulant activity though inhibition of COX in platelets.
All of the above are true

A

Acetylsalicylic acid (Aspirin) exhibits anticoagulant activity though inhibition of COX in platelets.

124
Q

All of the following statements about Drugs of abuse are correct, except:*

Many of these drugs act directly on dopaminergic and norepinephrinergic neurotransmitter systems.
Most compounds contain a basic amino-group.
Rapid emergency room screening methods are Thin-layer chromatography and EMIT.
Employment screening and forensic testing would require an independent confirmatory technique from the screen method.
The tricyclic antidepressants are used to treat psychotic states such as schizophrenia.

A

Most compounds contain a basic amino-group.

125
Q

The mechanisms of drugs of abuse include: *

stimulate pathways that utilize norepinephrine as the neurotransmitter
binds to sodium-potassium activated ATPase thereby blocking sodium efflux Undergo metabolism in the extramitochondrial microsomal system in hepatocytes block sodium influx and secondary calcium influxes
1st, 2nd, & 3rd choices only
2nd, 3rd, & 4th choices only
1st, 3rd, & 4th choices only
All of the above

A

1st, 2nd, & 3rd choices only

126
Q

Muddy brown urine casts with high urine protein is usually seen in _____. *

Post-renal azotemia
Prerenal azotemia
Intrarenal azotemia

A

Intrarenal azotemia

127
Q

Which findings would be diagnostic of a severe liver failure? *

serum bilirubin
total protein -
Lactate Dehydrogenase -
De Ritis ratio-

A

serum bilirubin- INCREASED
total protein - DECREASED
Lactate Dehydrogenase - INCREASED
De Ritis ratio- INCREASED

TIRED YEAR (16 decks)

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