Pharmacology| Treatment of High Cholesterol.

Question 1

Describe MOA, and Indications of Cholestyramine

Answer 1

1. Indications- Used to treat pruritis caused by bile duck blockage. Lowers Cholesterol
2. MOA- lowers LDL by increasing LDL receptors.
   *Poorly tolerated

Question 2

Describe the Agents, MOA, Indications, A/E of Statins

Answer 2

Agents
1. Simvastatin
2. Fluvastatin
3. Atorvastatin
4. Rosuvastatin
5. Pravastatin
MOA- Inhibits HCG Co A reductase in the liver
Indications- Stroke and Myocardial Infarction
A/E-
1.Rhabdomyolysis
2.Myalgia
3.Liver Problems(transient)

Question 3

Describe the Agent, Mech of action and A/E of GIT Cholesterol Blockers

Answer 3

1. Agent-Ezetemibe or Ezetrol
2. MOA- Inhibtis NPC1L1 receptor.
3. A/E-Well tolerated
4. Add on to therapy with Statins

Question 4

Describe the Agent, Indications, A/E of PCSK9 inhibitors.

Answer 4

*Agent-Evolocumab
Indications
1. Heterozygous Familial Hypercholestereamia
2. Atherosclerotic Cardiovascular Diseases
A/E
1. Injection SIte Reactions
2. Back
3. Influenza
4. Upper Respiratory Tracks
5. Nasopharyngitis

Question 5

Describe the Agents, Indications, A/E and MOA of Fibrates

Answer 5

1. Agents- Bezafibrates and Gemfibrozil
2. Indications- Mixed Dyslipidaemia and Type-1 Diabetes mellitus
3. A/e- same as Statins
4. MOA- Stimulates Apo A1/2, to increase HDL and decrease LDL