Pathophysiology: Cellular Function Flashcards

1
Q

Describe basic cellular function.

A

The ability to exchange materials with their immediate surroundings

Obtain energy from organic nutrients

Synthesize complex molecules

Replicate themselves.

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2
Q

Describe basic cellular structure

A

The basic cell components include the cytoplasm, organelles, cell membrane, nucleus, and cytoskeleton .

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3
Q

Cytoplasm structure?

A

A colorless viscous liquid containing water, nutrients, ions, dissolved gases, and waste products. (where cellular work takes place)

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4
Q

Organelle’s structure?

A

Cytoplasm surrounds the nucleus and perform the work of maintaining the cells life.

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5
Q

Cell OR plasma membrane structure?

A

Lipid bilayer OR fatty double covering makes up the cell membrane.

However, the outside is less fatty and charged.

The interior surface of this membrane is uncharged and made up of lipids.

Fatty covering allows some molecules to pass through & not others

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6
Q

Discuss how cells exchange materials.

(Passage across the cell membrane may occur through several mechanisms)

A

Facilitated diffusion(active/passive)

Osmosis,

Active transport

Endocytosis(pino/phagocytosis)

Endocytosis/Exocytosis.

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7
Q

Identify how cells obtain energy.

A

Cells obtain energy from the breakdown of glucose (a type of carbohydrate) & and the breakdown of triglycerides (type of fat) if these are unavailable cells can get energy from protein.

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8
Q

(1st step) Identify how cells produce energy.

A

1st- food enters GI tract to be broken down into sugars, amino, & fatty acids.

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8
Q

2nd step of the production of energy

A

Molecules that are entered by food are either -CONVERTED to larger molecules (glucose to glycogen, amino acids to proteins)

-STORED until needed

-OR METABOLIZED to make ATP.

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8
Q

Explain how cells replicate.

A

Proliferation and Mitosis are two ways cells can reproduce.

Proliferation is when cells divide & replicate.

Mitosis is when the cell divides into two separate cells which results in two genetically identical and equal daughter/diploid cells.

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9
Q

Explain how cells specialize.

A

Cells specialize through the process of differentiation where the cells become specialized in their own type, function, structure, and cell cycle.

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10
Q

(Atrophy) Describe common cellular adaptions & possible reasons for the reoccurrence of each.

A

Atrophy occurs because of decreased work demands on the cell. Cells decrease in size and number because of this.

Causes of this is disuse, denervation (loss of nerve supply), inadequate nutrition ETC.

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11
Q

(Hypertrophy) (occurs in cardiac/skeletal muscle) Describe common cellular adaptions & possible reasons for the reoccurrence of each.

A

When the cells increase in size in an attempt to meet increased work demands.

It can happen as a normal or abnormal change (to adapt to or accustom to abnormal within the body)

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12
Q

(Hyperplasia) (happens in menstruation/wound healing) Describe common cellular adaptions & possible reasons for the reoccurrence of each.

A

An increase in the number of cells in an organ or tissue. This increase occurs only in cells that have the ability to perform, mitotic division like (epithelial cells). This process is a result of normal stimuli.

This process can also be abnormal when caused by excessive hormone or growth factors.

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13
Q

(Metaplasia) Describe common cellular adaptions & possible reasons for the reoccurrence of each.

A

This process in which one adult cell is replaced by another cell type.

This change is initiated by chronic irritation and inflammation by a virulent cell line emerges.

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14
Q

(Dysplasia) (abnormal process) Describe common cellular adaptions & possible reasons for the reoccurrence of each.

A

In this process cells mutate into cells of a different size, shape, and appearance. Reversible by removing trigger.
(respiratory/reproductive tracts are common sites)

15
Q

List common causes of cell damage

A

Mechanical forces

Extreme temperature

Pollution

Drugs

Low oxygen levels (hypoxia)

Nutritional imbalances (metabolic waste accumulation, ATP depletion

16
Q

Discuss cancerous cellular damage.

A

Carcinogenesis is the process by which cancer develops, occurs in three phases: initiation, promotion, and progression

17
Q

Describe metastasis

A

A hostile secondary development growth at a distance from a primary site of cancer

18
Q

What regulates proliferation?

A

Genes and growth factor proteins regulate this process by either stimulating or suppressing it.

Factors like the environment or nutrition are examples of positive/negative factors.

19
Q

What is differentiation stimulated by?

A

which is stimulated by gene expression & growth factor ETC

20
Q

What is Apoptosis?

A

Programmed cell death

Eliminates unwanted , injured, dead cells

Self destructs & breaks into fragments

21
Q

What is Necrosis?

A

Cells swell and burst & Initiate inflammatory response

22
Q

Describe TMN cancer staging.

A

Evaluates the tumor size, nodal involvement, and metastatic progress