14. Hormones and Bisphosphonates

Question 1

TSH values above 4.2 indicates hypo or hyper thyroids?

How about below 0.2?

Answer 1

TSH values >4.2 = hypothyroidism

TSH values >0.2 = hyperthyroidism

Question 2

Levothyroxine is the synthetic form of which hormone?

How often is serum TSH monitored during titration?
How long does it take before a max dosage is established?

Answer 2

Thyroxine

Every six weeks

Six months

Question 3

Hypothyroidism can lead to an exaggerated response from what medications?

Answer 3

CNS depressants such as sedatives, narcotics, and St. John’s Wort

Question 4

Thyroid Storm - Symptoms?

Answer 4

Tachycardia, fever, sweating, confusion, diarrhea, unconsciousness

Question 5

Diabetes diagnoses

• A1C is less than or equal to?
• Fasting blood glucose is less than or equal to?
• Two hour plasma glucose is less than or equal to

Answer 5

1. <6.5
2. <126 mg/dL
3. <200 mg/dL

Question 6

Bisphophonates - MoA

How does this interact with other drugs?

Answer 6

Reduces turnover of bone by inhibiting and promoting apoptosis of osteoclasts

Reduces vascularity of bone, limiting antibiotic reach