16. Anti-virals

Question 1

Antivirals - Goals of Medication (2)

Answer 1

1. Reduce severity of illness

2. Decrease rate of transmission

Question 2

Antiviral targets (4)

Answer 2

1. Virus adsorption
2. Virus-host cell fusion
3. Viral RNA/DNA synthesis
4. Viral enzyme activity

Question 3

What does HAART stand for?

Answer 3

Highly active anti-retroviral therapy

Question 4

Common dental conditions associated with HIV/AIDS (6)

Answer 4

1. Dry mouth
2. Thrush
3. Swollen glands
4. Periodontal disease
5. Aphthous ulcers
6. Herpetic lesions

Question 5

Goals of HIV treatment (4)

Answer 5

1. Reduction of HIV-related morbidly and mortality
2. Improved quality of life
3. Restoration/improvement of immune function
4. Suppression of HIV replication to undetectable levels

Question 6

At what level of CD4 count should you initiate anti-retroviral therapy?

Answer 6

> 200 cells/mm3

Question 7

Herpes simplex - Treatment goals

Answer 7

1. Limit duration and recurrence of active infection

2. Relieve associated symptoms of active infection

Question 8

Acyclovir (MoA)

How is it prescribed? (dosage, etc)

Answer 8

Inhibits viral DNA polymerase and terminates chain elongation

Topical (5% acyclorvir) - Most effective in prodigal stage