14. Indolent and aggressive non-Hodgkin lymphomas: distinctive features, clinical manifestation, evolution, principles of treatment. Flashcards
etiology of non hodgkin lymphoma ?
immune deficieny
congenital wiskott aldrich syndrome
organ transplant with cyclosporin
DNA repair
= ataxia telengeictasia
xeroderma pigmentosum
h plori inflmamion of stomach
sjögren syndrome
viral
EBV and burkitt lymphoma
HHHV8 (human herpes virus 8 )
HTLV -1 (human t cell lymphotropic virus 1 )
what is the immunohistochemsitry of non hodgkin lymphoma ?
what is the etiology of diffuse large b cell lymphoma ?
etiology of burkitt lymphoma and its chareteristic according to epidemiology ?
etiology of matle cell lymphoma ?
etiology of follicular lymphoma ?
etiology of mariginal zone / maltoma
another name for lymphoplasmaocytic lymphoma ?
B cell = most common = CD20 nd CD19
T cell = CD3 AND CD4
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b cell aggressive =
diffuse large cell b cell lymphoma - affecting the BCL-2 GENE
burrkitt lymphoma strong association of EBV chromosomal translocation from 8:14 over expression of the MYC gene = in africa burkitt lymphoma poduces extranodal involvemnt of the jaw
OUTSIDE OF AFRIVCA =
EXTRANODAL INVOLVEMENT OF THE ABDOMEN ileojejunal junction = and less associated with EBV
mantle cell lymphoma
translocation of 11 14
over expression of BCL-1 causes over expression of
cyclin d1 gene over expression
and indolent = low grade
follicular lymphoma
chromosomal translocation between 14 and 18
marginal zonal lymphoma = associated with MALT
= which chronic inflammation of h pylori in th lining of the stomach
lymphoplasmocytic lymphoma
produce immunoglobulin which are high in the blood
blood thick and vicious
WALDENSTROM MACROGLOBULINEMA
what are the signs and symptoms of non hodgkin lymphoma ?
lymphadenopathy
b symptoms = mor eprevelant in aggresive lymphoma
extranodal liver hepatoslenomegaly itching ascitis
compression syndromes
airway obstruction
superior vena cava compression
some b cell lymphoma secrete antibodies = hyperviscocity
what is the diagnosis ?
excisional biopsy
burkitt lymphoma = starry sky
h and e staining
immunohistochemistry to show to confirm the cells are lymphois LCA flow cytometry cd19 and cd20 = b cell lymphoma CD3,4,CD8 - t cell lymphomas
immunoglobulin measurements
uric acid - in high grade non hodgkin lymphoma
HIV TESTING
CT scan
lumbar puncture - AIDS LYMPHOMA
T CELL LYMPHOBLASTIC LYMPHOMA
for staging in non hodgkin lymphoma each stage is there further classified into a , b , e such as how ?
A = no b symptoms
b = sympotms
E = spreadinto tother organ involvemne
what is the treatment for non Hodgkin lymphoma ?
for indolent lymphomas observation only radiotherapy at sight of problem systemic chemotherapy = CHOP , fludarabine rituximab = antibody against cd20 stem cell bone marrow transplant
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aggressive
stage 1 and 2 potentially curable CHOP 6 CYCLES CHOP 3 CYCLES FOLLOWED BY RADIOTHERAPY if localised (cyclophosphamide , adriyamyicn oncovicin , prednisone )
advanced
R-CHOP
we can have prophylaxis of CSF = intrathecal therapy of methotrextae
in young = autologous stem cells transplant
what is a t cell non hidgkin lymphoma ?
lymphoblastic lymphoma
occurs in males
medisatinal mass
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mycosis fungoides
malignancy of helper t cells
treatd with elctron beam radiation and uv , topical alylayting agents
