Ovarian Cancer Flashcards
What are the histological types of Ovarian cancer?
1) Epithelial tumors
2) Sex cord stromal tumors
3) Germ cell tumors
What is the most common histological type of Ovarian cancer?
Epithelial tumors
What is the rarest histological type of Ovarian cancer
Germ cell tumors
What is the lifetime risk of developing Epithelial Ovarian Cancer with BRCA 1 mutation?
50%
What is the lifetime risk for developing Epithelial Ovarian Cancer with BRCA 2 mutation?
30%
What is the lifetime risk for developing Epithelial Ovarian Cancer with Lynch 2 Syndrome mutation?
10%
What is another name for Lynch 2 Syndrome?
Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
When do we genetic testing for mutations that → Ovarian Cancer?
1) Early onset Breast or Ovarian cancer (i.e., under 40/50 years old)
2) Family history of early onset Breast or Ovarian cancer
3) Women with high grade serous cancer
why do we do genetic testing for Ovarian cancer?
To trace other family members
What genetic mutations are associated with Epithelial Ovarian Cancer?
1) BRCA 1
2) BRCA 2
3) Lynch 2 Syndrome
What do you offer women with BRCA mutation?
Risk-reducing Bilateral Salpingo - Oophorectomy (BSO), between the ages of 35 & 40 or earlier if family complete
What do you offer women with Lynch 2 Syndrome mutation?
Risk- reducing Total Abdominal Hysterectomy & Bilateral Salpingo - Oophorectomy (TAH-BSO)
What are the most common presenting complaints in a patient suspected of Ovarian Cancer?
1) Asymptomatic in earlier stages
2) Pelvic & / or Abdominal pain
3) Non-specific GI symptoms
4) Metastatic signs & symptoms
5) P/V bleeding
6) Rectal bleeding
Why would a patient with Ovarian Cancer complain of dyspnea?
The dyspnea could be due to:
1) Ascites (pushing the diaphragm up)
OR
2) Pleural Effusion
What are the Non-specific GI complaints in a patient suspected of Ovarian Cancer?
♦ Dyspepsia
♦ Bloating
♦ Diarrhea & / Constipation
♦ Urinary frequency / urgency
♦ Weight loss
♦ Early satiety
♦ Nausea & vomiting
♦ Fatigue
♦ Dyspnea