Alternative Pathway of Complement System Flashcards
1
Q
The complement complexes not required in the alternative pathway are…
A
C1, C2 and C4
2
Q
(Alternative) C3 can be converted into C3a and b…
A
Spontaneously
3
Q
In the alternative pathway, C3b…
A
- Can bind to healthy cell membranes
- Is inactivated by inhibitory proteins in the membrane
- Creates complement cascade by binding to pathogen membrane
- Binds to plasma protein Factor B and facilitates it’s cleavage by Factor D into Ba & Bb
4
Q
Bb remains bound to […] and their complex acts as a […]
A
C3b; C3 convertase
