Drugs

Question 1

What is the class and MOA of Paclitaxel?

Answer 1

Taxanes

Prevents microtubule depolymerization - cell cycle arrest in Anaphase

Question 2

Class and MOA of Vinblastine

Answer 2

Vinca alkaloid

Inhibits tubule polymerization –> inhibits mitotic spindle formation

Question 3

Class and side effects of Vincristine

Answer 3

Vinca alkaloid

Peripheral neuropathy

Question 4

Class and side effects of Vinblastine

Answer 4

Vinca alkaloid

Bone marrow suppression (preferred for Hodkins lymphoma)

Question 5

In what phase of the cell cycle do Vinca Alkaloids cause mitotic arrest and how?

Answer 5

Metaphase

Inhibition of tubule polymerization prevent microtubules from binding to kinetochores –> failure at spindle checkpoint

Question 6

In what phase of the cell cycle do Taxanes cause mitotic arrest and how?

Answer 6

Anaphase

Inhibition of microtubule depolymerization –> cell cannot break down microtubules to pull sister chromatids apart –> arrests at onset of anaphase

Question 7

What medication is preferred in the treatment of Hodkin’s lymphoma?

Answer 7

Vinblastine

Question 8

What is the method of action for aspirin?

Answer 8

Aspirin inhibits COX with stops the release of TxA –> less platelet activation - aids in primary prevention

Question 9

What is the method of action for eptifibatide?

Answer 9

Competitive inhibitor of GpIIb receptor –> prevents new clots by inhibiting platelet aggregation

Question 10

What is the method of action of clopidogrel?

Answer 10

Blocks ADP from binding with P2Y12 receptor –> inhibits GpIIb receptor activation

Must go through first pass metabolism to be activated