Topic 1 - How Drugs Work

Question 1

Lock and Key Analogy (Endogenous Ligand)

Answer 1

Receptor = Lock
Endogenous Ligand = Key

Ligand fits into Receptor, can “turn” activating the receptor

Question 2

Lock and Key Analogy (Drug)

Answer 2

Drug = Similar Shaped Key

Drug mimics the Endogenous Ligand, can also fit into, “turn” and activate the receptor

Question 3

Lock and Key Analogy (Antagonists)

Answer 3

Antagonist = Pencil

Blocks drug from entering the receptor and preventing it from activating receptor

Question 4

Lock and Key Analogy
(Positive Allosteric)

Answer 4

Positive Allosteric Modulators = Oil

Increases drugs ability to respond by making it respond faster

Question 5

Lock and Key Analogy
(Negative Allosteric)

Answer 5

Negative Allosteric Modulators = Honey

Decreases drugs ability to respond by making it respond slower