Antibiotics Flashcards
1
Q
Penicillin MOA
A
Beta-lactam ring interferes with peptidoglycan cross-linking in bacterial cell wall
2
Q
How does ampicillin/amoxicillin differ from penicillin?
A
They are aminopenicillins, which add gram-negative (E coli, Salmonella) coverage and additionally Listeria (Gram+)
3
Q
What are the extended spectrum penicillins?
A
Piperacillin and ticarcillin - anti-Pseudomonas and Proteus
4
Q
Beta-lactamase inhibitors add activity to what organisms?
A
H flu
Bacteroides fragilis
Some Enterobacteriaceae (enteric Gram-)
5
Q
How is vancomycin “red man syndrome” prevented?
A
Decrease rate of infusion
Administer H1-antagonist (eg diphenhydramine)
6
Q
Fluoroquinolone MOA
A
Inhibit bacterial DNA gyrase and topoisomerase II, inhibiting DNA replication
7
Q
What antibiotics cover anaerobes?
A
- Metronidazole
- Clindamycin
- Pip-tazo (Zosyn)
