Transplant Flashcards
1
Q
Azathioprine
A
Purine analog - inhibits lymphocyte replication
Bone marrow suppression, hepatotoxicity
2
Q
Mycophenolate
A
Bone marrow suppression, GI disturbance
3
Q
Tacrolimus, cyclosporine
A
Inhibition of IL-2 transcription
Vasoconstrictive:
1. Nephrotoxicity (acute or chronic), hyperkalemia and hyperuricemia
2. Hypertension
3. Neurotoxicity, tremors (resting or intention)
Hyperglycemia due to impaired secretion of insulin (tacrolimus > cyclosporine)
Gingival hypertrophy (cyclosporine > tacrolimus), hirsutism, alopecia
GI disturbance
4
Q
What to do if CMV
A
Stop mycophenolate antimetabolite immune suppression
