lecture 7 - ACE inhibitors & ARBs Flashcards
What is the full name for the RAAS system?
Renin Angiotensin Aldosterone System
What vasodilator increases in concentration due to ACE inhibition?
Bradykinin
What does ACE stand for?
Angiotensin converting enzyme
What is a common example of an ACE inhibitor?
Enalapril
What is the suffix used for ACE inhibitor drug names?
-pril
What is the role of ACE?
Assists in the conversion of Angiotensin 1 to Angiotensin 2
What are the direct effects of decreasing levels of Ang II with an ACE inhibitor?
Reduced vasoconstriction and therefore systemic vasodilation and reduced peripheral resistance
What is the effect of reduced aldosterone release due to ACE inhibitors?
Increased Na+ and H2O excretion (diuresis), which reduces plasma volume and therefore pressure
What are the indications for ACE inhibitors such as Enalapril?
Hypertension, chronic heart failure
What are the common adverse effects of ACE inhibitors?
Persistent dry cough, oedematous rash, foetal abnormalities (in pregnancy)
What is the full name for ARBs?
Angiotensin receptor blockers
What is a commonly used ARB?
Candesartan
What is the mechanism of action of ARBs?
They are antagonists of AT1 receptors, which prevents Ang II from binding and blocking downstream effects.
What is the difference between the effects of ARBs and ACE inhibitors?
ARBs have no effect on bradykinin levels, while ACE inhibitors increase bradykinin to cause a vasodilatory effect.
What are the indications for ACE inhibitors?
Hypertension, Heart failure
