1. Intro Lecture Flashcards
1
Q
What is LD50
A
The median lethal dose
→ i.e. the dose required to kill 50% of a test population
2
Q
What are some characteristics which make it so a substance is lethal to some people but not everyone? (7)
Like why is the LD50 only 50% of the population and not everyone?
A
- acute or chronic?
- what time period?
- how much do you weigh?
- child or adult?
- are you pregnant?
- male or female?
- genetically predisposed?
3
Q
What is the central paradigm of toxicology
A
Risk = Exposure x Hazard
4
Q
What is risk?
A
How dangerous?
The probability of harm.
5
Q
What is exposure?
A
How much?
6
Q
What is hazard?
A
How toxic?
The possibility of harm, the intrinsic harmfulness of a chemical
