Cystic Fibrosis

Question 1

Mutation in CFTR channel can lead to

Answer 1

Inability to move chloride to the cell surface, resulting in thick and sticky mucus

Question 2

What 2 factors compose pulmonary exacerbation?

Answer 2

. Respiratory symptoms
. Decline in lung function

Question 3

What are the two most common pathogens for CF exacerbation?

Answer 3

. Pseudomonas aeruginosa
. Methicillin resistant staphylococcus aureus

Question 4

Common risk factors for multi drug resistant organisms

Answer 4

. History of colonization
. Recent hospitalization
. Previous ABX use

Question 5

True or false: In CF, synergy does not mean covering holes in therapy, but refers to double coverage of the same bug to ensure eradication

Answer 5

True

Question 6

True or false: Monotherapy is preferred to double coverage therapy in pseudomonas exacerbation of cystic fibrosis

Answer 6

False. Double coverage is preferred, insufficient evidence for single agents

Question 7

Which agents may be used for pseudomonas double coverage in cystic fibrosis patients?

Answer 7

.Tobramycin, amikacin, ciprofloxacin +
. Zosyn, ceftazidime, cefepime, carbapenems*

Question 8

Agents used for Stenotrophomonas maltophilia coverage in cystic fibrosis

Answer 8

Bactrim*, Levofloxacin, ceftazidime, zosyn

Question 9

Agents used for MRSA coverage in cystic fibrosis

Answer 9

Vancomycin, linezolid, Bactrim, ceftaroline, clindamycin