Prions

Question 1

Diffuse infection if the brain parenchyma (encephalitis) almost associated with meaningful inflammation

Answer 1

Meningoencephalitis

Question 2

Diffused infection of the brain parenchyma sometimes with simultaneous involvement of the spinal cord

Answer 2

Encephalomyelitis

Question 3

Lesions appear, gradually demyelinatingbthe nerve cells (white matter) of the brain, causing loss of coordination and weakness

Answer 3

JCVirus( Progressive Multifocal leukorncephalopathy) PML

Question 4

Described PML (JCVirus)

Answer 4

Question 5

JCvirus (PML) is seen in what individuals?

Answer 5

Question 6

What is the epidemiology of JCVirus (PML)

Answer 6

Question 7

What is the pathogenesis of JC virus?

Answer 7

Question 8

Morphology if JC virus

Answer 8

Family- polyoma virus
Non-enveloped DNA virus

Question 9

What are the symptoms of PML (JCvirus)?

Answer 9

Question 10

Labs and test to confirm JC virus (PML)

Answer 10

Question 11

What is this disease?

Answer 11

SSPE (SUBACUTE SCLEROSING PANENCEPHALITIS)

Question 12

Describe SSPE

Answer 12

Question 13

What is the pathogenesis of SSPE

Answer 13

Question 14

What are the symptoms of SSPE?

Answer 14

Question 15

What is the morphology of SSPE? Focus on the Genome type and differentiate from PML(jcvirus)

Answer 15

Question 16

Classical CJD and n.variant CJD

Answer 16

Question 17

Transmissinle spongiform encephalopathy

Answer 17

Prions

Question 18

What’s is Prion disease? A transmissible spongiform encephalopathies

Answer 18

Question 19

Prion disease affects both humans and animals. What are the different types respectively?

Answer 19

Question 20

Important: pathogenesis of Prions disease- tansmissible spongiform encepyalopathies

Answer 20

Question 21

What are prions? and it’s location?

Answer 21

Question 22

Important: How are abnormal prion formed?

Answer 22

Question 23

Important! Prions are unique from other infectious agents and how are they destroyed?

Answer 23

Question 24

Compare Scarpie prion protein (PRPsc) and (normal) cellular prions protein

Answer 24

Question 25

Comparison of classic viruses and prions

Answer 25

Question 26

Describe CJD (cruetzfeldt-jakob disease) and ita 3 forms

Answer 26

Question 27

What are the major clinical presentation of CJD (pay attention to the asterisks)

Answer 27

Question 28

How is CJD transmitted?

Answer 28

Question 29

What is the features, epidemiology, transmission of the New Variant CJD (nvCJD)

Answer 29

Question 30

Important summary of PML, SSPE, CJD and nvCJD

Answer 30

Question 31

Summary of Tetanus and Botulism

Answer 31

Question 32

Describe tetanus

Answer 32

Question 33

Virulence mechanism of tetanus and prevention

Answer 33

Question 34

What is the morphology, physiology, transmission, reservoir

Answer 34

Question 35

What are the two types of infection from Botulism?

Answer 35

In infants- spores germinate in gut and produce toxin

Food borne Botulism is from ingesting preformed toxins from canned vegetables

Question 36

What is the virulence and effect of acetylcholine?

Answer 36

Question 37

What are the signs and symptoms of botulism

Answer 37

Question 38

What is the morphology and physiology, epidemiology, Reservoir of Botulism

Answer 38

Question 39

Causes of Infant Botulism, signs and symptoms

Answer 39

Question 40

Describe wound and Inhalation Botulism

Answer 40

Question 41

Lab diagnosis, treatment, clinical use and prevention of Botulism

Answer 41

Question 42

Clinical case 1

Answer 42

Question 43

Clinical case #2

Answer 43