lipid lowering agents

Question 1

first type of drug used for hyperlipidemia?

Answer 1

statin

Question 2

atorvastatin action

Answer 2

-blocks cholesterol production
-reabsorbs cholesterol buildup in plaques
-decreases LDL & increases HDL

Question 3

atorvastatin indications

Answer 3

-hyperlipidemia, CAD, post-CVA

Question 4

atorvastatin adverse reaction

Answer 4

-myopathy
-hepatoxivity

Question 5

atorvastatin drug interactions

Answer 5

grapefruit juice

Question 6

atorvastatin assessment

Answer 6

monitor:
-creatinine
-kinase levels
-renal function (myopathy)
-LFTs at 12 weeks then q6 months (hepatotoxicity)

Question 7

atorvastatin teaching points

Answer 7

-report muscle weakness or tenderness
-avoid grape fruit juice

Question 8

what is the second line of medication for hyperlipidemia?

Answer 8

ezetimibe

Question 9

ezetimibe adverse effects

Answer 9

-myopathy
-hepatoxicity - use with statins increased risk

Question 10

ezetimibe drug to drug interactions

Answer 10

-statins
-cholestyramine
-gemfibrozil

Question 11

ezetimibe assessment

Answer 11

monitor:
-creatinine kinase levels
-renal function (myopathy)
-LFTs

Question 12

ezetimibe teaching points

Answer 12

report muscle weakness or tenderness

Question 13

colesevelam action

Answer 13

decreases LDL

Question 14

colesevelam drug to drug interactions

Answer 14

-many b/c of interference with absorption
-take 1 hour before or 4 hours after other meds

Question 15

colesevelam assessment

Answer 15

monitor bowel movements

Question 16

colesevelam teaching points

Answer 16

-increase fiber and fluids
-take mild laxative if needed for constipation

Question 17

gemfibrozil action

Answer 17

-decreases triglyceride
-increase HDL

Question 18

gemfibrozil adverse effects

Answer 18

-mild GI distress
-gallstones
-myopathy
-hepatotoxicity

Question 19

gemfibrozil drug to drug interactions

Answer 19

-statins
-warfarin

Question 20

gemfibrozil teaching

Answer 20

-monitor for abdominal pain
-muscle aches
-jaundice