Hockermanm Flashcards
what is the substrate protein for factor IIa?
fibrinogen/fibrin
Hemophillia A is a deficiency in what
8
Hemophillia B is a deficiency in what
9
where are clotting factors produced?
liver (except von Willebrand)
where is von Willebrand produced?
endothelium, subendothelium, megakaryoctyes
liver disease can have a _____ effect on anticoag
unpredictable
recalcification (bleeding time)
2-4 minutes
aPTT time and use
26-33 seconds
test heparin efficacy
prothrombin time PT
11-14 seconds
test warfarin efficacy
warfarin inhibits factors __
2, 7, 9, 10, protein C and S
drugs that increase warfarin effect
increase INR
broad spectrum antibiotics
metronidazole, amiodarone, fluconazole, bactrim, ciprofloxacin
drugs that decrease warfarin effect decrease INR
rifampin
vitamin K
warfarin overdose? no major bleeding
vitamin K if INR >10
warfarin overdose? major bleeding
prothrombin complex concentrate with vitamin K
heparin reversal agent
protamine sulfate
reversal agent for apixaban and rivaroxaban
andexanent alpha
black box warning andexanet alpha?
thrombolytic events
peptide of leach saliva gland
hirudin