Pharma Flashcards
Polar vs Nonpolar drugs
Polar - water soluble and not readily absorbed by cell membrane due to their hydrophilic properties.
NP - lipid soluble, readily absorbed by cell membrane due to their lipophilic properties.
Ionized vs unionized drug
I - lipophobic, cant penetrate lipid membranes
U -lipophikic, can penetrate lipid membranes
Why is epi used with local anesthetics
Because of its alpha adrenergic agonist receptor properties
what is the AM MoA of chloramphenicol?
binding to the bacterial 50S ribosomal subunit and inhibition of peptidyltransferase activity
What is the AM MoA of erythromycin
reversible binding to the bacterial 50S ribosomal subunit and inhibition of ribosomal translocation
What is the AM MoA of fluoroquinolones?
Inhibition of DNA synthesis by disruption of DNA gyrase activity
What is the AM MoA of aminoglycosides?
irreversible binding to the bacterial 30S and possibly 50S subunit, resulting in abnormal codon:anticodon recognition
What is the MA MoA of tetracyclines?
binding to the bacterial 30s subunit, resulting in interference with aminoacyl tRNA binding to the acceptor (A) site
What is the MoA of penicillin?
Prevention of peptidoglycan synthesis by binding to transpeptidase
MoA of Spironalactone
MoA of furosimide
MoA of Thiazide
F - inhibition of chloride transport in the Loop of Henle
S - inhibition of aldosterone receptor
T - decreases Na and Chloride resorption in distal tubule
MoA of class 1 antiarrhythmics
NA channel blocade
MoA of class 3 antiarrhythmics
K channel blocade
MoA of Ammonium Chloride
Decrease chloride resorption in the loop of Henle, causing diuresis
MoA of carbonic anhydrase inhibitors.
Decrease sodium resorption in the distal tubule.
