ANTI FUNGAL

Question 1

Azoles (-canazole)

Answer 1

**Azoles **(-canazole)
Mechanism of action:
- Cell membrane - ergesterol inhibitors
Examples:
- Fluconazole
Adverse effects:
- Elevated liver enzymes
- Diarrhoea
- Abdominal pain
- Nausea/vomiting
- Rash
- Thrombocytopenia (low platelets)
- Anaphylaxis
- Blood dyscrasias
- Hepatotoxicity

Question 2

3 CLASSES OF ANTIFUNGAL

Answer 2

Antifungals
1. Azoles
2. Echnicandins
3. Polyenes

Question 3

Polyenes

Answer 3

Polyenes
Examples:
- Amphotericin B
- Nystatin
Mechanism of action:
- Cell membrane - ergesterol binder
Indication:
- Serious fungal infections
Adverse effects:
- Nausea
- Vomiting
- Nephrotoxicity
Contraindications:
- Renal problems
- High doses (extra caution)
- Other nephrotoxic medications

Question 4

Echinocandins (-fungin)

Answer 4

Echinocandins (-fungin)
Mechanism of action:
- Cell wall - glucan inhibitors
Examples:
- Caspofungin
Adverse effects:
- Hypokalaemia
- Anaphylaxis
- Nausea
- Vomiting