Into/out of the TCA

Question 1

Other ways to get Energy other than carb metabolism

Answer 1

• amino acids
• fatty acids

Question 2

If pyruvate is converted to lactate, why is there potential energy lost?

Answer 2

under Anaerobic conditions, and due to lactate not being fully oxidized yet.

If there is further oxidation, between CO2 and Water, will get more ATP due to Ox-phos.

Question 3

WHat to do with TCA?

Answer 3

• several fuels (AA, pyr, FA) which are converted to acetyl-coA
• rxns occur in the mitochondria… Glycolysis occurs in cyt, need a way to move from cytosol to the mitochondria. So need transport proteins
• OA is a crossroad metabolite (TCA and GNG)