TCA's overall chemical strat

Question 1

TCA

Answer 1

eukaryotic enzymes in the mitochondria. What must happen?
Need to have transporters involved.

Question 2

Oxidation of C involves,,,

Answer 2

loss of Hydride or gain of bonds to O with ∆G saved in NADH, FADH2 and GTP.

GTP can be converted to ATP

Question 3

net rxn TCA

Answer 3

OA formed in step 8 is used in step 1:
3 NAD+ + FAD + GDP + Pi + Acetyl-CoA + 2H2O —-> 3NADH + FADH2 + GTP + CoA + 3H+

Question 4

Two phases of TCA

Answer 4

phase 1: Rxns 1-4… oxidative phase

phase 2: Rxns 5-8… Regenerative phase, are reversible.

Question 5

What is the key idea/overall chem strat???

Answer 5

Acetyl-Coa oxidation in TCA will happen as it does chemically because need carbanion TS stabilized via a/b-keto acids.

Come back to this idea as you study.