nausea and vomiting

Question 1

whereis vomiting centre

Answer 1

medullla

Question 2

what sort of receptors in medulla for vominiting

Answer 2

muscarinic

Question 3

what receptors in the chempreceptor trigger zone for vomiting

Answer 3

D2 (dopamine)
5-HT (seratonin)
NK1

Question 4

CTZ triggers the… which triggers the

Answer 4

vominitng centre
emetic reflex

Question 5

which receptors involved in motion sickness

Answer 5

H1 and muscarinic

Question 6

which cells in the stomach release what in response to cytotoxicity

Answer 6

enterochromaffin
serotonin

Question 7

which nerve carries vomity information from the stomach to the vomiting centre

Answer 7

vagus

Question 8

5-HT3 antagonist names, use and mechanism of action

Answer 8

…tron eg ondansetron

chemotherapy induced sickness

block serotonin on vagus and GI receptors -> no signal to vomiting centre

Question 9

NK1 receptor antagonists are used for…
names…
mechanism of action

Answer 9

PONV, chemotherapy-induced N and v
aprepitant, …pitant

blocks NK1 receptors in CNS so Substance P can’t bind

Question 10

common anti-emetic drigs

Answer 10

dexamethosone
NK1 receptor antagonists
5-HT receptor antagonists
D2 antagonists

Question 11

what class of drug is domperidone

Answer 11

D2 antagonist

Question 12

examples of D2 antagonists

Answer 12

domperidone
metoclopramide

Question 13

which is the most commonly used class of anti-emetics

Answer 13

D2