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Cell Biology- Samiyah > The Extracellular Matrix > Flashcards

The Extracellular Matrix Flashcards

1
Q

What is the extracellular matrix

A
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2
Q

What are MMPs

A

Proteases secreted by cells if cells want to move by eating the surrounding cells

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3
Q

What is a fibroblast

A

A fibroblast is a type of cell that contributes to the formation of connective tissue, a fibrous cellular material that supports and connects other tissues or organs in the body. Fibroblasts secrete collagen proteins that help maintain the structural framework of tissues.

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4
Q

How do cells make the ECM

A

Components of the ECM are produced intracellularly by resident cells and secreted into the ECM via exocytosis. Once secreted, they then aggregate with the existing matrix. The ECM is composed of an interlocking mesh of fibrous proteins and glycosaminoglycans (GAGs).

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5
Q

What are the 3 major classes of ECM macromolecules

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6
Q

What are GAGs

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7
Q

What are the functions of GAGs

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8
Q

What is a proteoglycan

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9
Q

What are some examples of proteoglycans

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10
Q

Where are these proteoglycans found

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11
Q

What are the functions of these proteoglycans

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12
Q

What are the characteristics of fibrous ECM proteins

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13
Q

What are the characteristics of collagen

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14
Q

What are some types of collagen

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15
Q

Where are these types of collagen found

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16
Q

What happens when these types of collagen are mutated

A
17
Q

What is elastin needed for

A

Elastin is held by cross links And is very stable

18
Q

What is the structure of arteries

A
19
Q

What is the general structure of non collagen glycoproteins

A
20
Q

What is the structure of fibronectin

A
21
Q

What is the function of fibronectin

A

Fibronectin (FN) is a multifunctional adhesive glycoprotein that plays an important role in tissue repair, in regulating cell attachment and motility

22
Q

How are the 3 classes of ECM components organised in the basal lamina

A
23
Q

What is the functions of the basal lamina

A
24
Q

What are the different locations of the basal lamina

A
25
Q

What is the structure of the basal lamina

A

The basal lamina consists of a mixture of collagens, laminin (glycoprotein), perlecan (heparan sulphate glycoprotein), entactin (glycoprotein). These proteins can bind to each other to make a highly crosslinked extracellular matrix

26
Q

How can the ECM affect cell behaviour

A

Via ECM receptors
Main type= integrins

Cell Biology- Samiyah (17 decks)

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