48. Endocrine dermatopathies in dogs and cats Flashcards

1
Q

Sex Hormone dependent dermatoses? Sertoli Cell tumour?

A

Sex-Hormone Dependent Dermatoses

SERTOLI CELL TUMOUR

Predisposed: Boxer; Shetland sheepdog; Poodle; Pekingese; Collie;

Mini Schnauzer; Any breed suffering from cryptorchism

Pathogenesis: Excessive secretion of oestrogen

Clinical signs

§ Preputial swelling § Dermatosis

§ Hyperpigmentation § Alopecia

§ Lichenification § ↓ Libido

§ Feminisation § Attracted by other males

§ Gynecomastia § BM depression

Treatment: Castration

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2
Q

Hyperadrogenismus in male dogs?

A

HYPERADROGENISMUS IN MALE DOGS

Leydig cell tumour

Predisposed: All breeds; Middle/old-aged

Clinical signs

§ Circumanal gland hyperplasia § Prostatitis

§ Tail gland hyperplasia § Perianal adenoma

§ Severe seborrhoea oleosa § Alopecia

Treatment: Castration

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3
Q

Testosterone Responsive Alopecia?

A

TESTOSTERONE-RESPONSIVE ALOPECIA

In castrated male dogs

Clinical signs

§ Symmetrical alopecia § Seborrhoea

§ Dry hair § Thin skin

§ Dull hair § Hypotonic skin

§ Lighter hair (initially) § Scaling

Treatment: Methyltestosterone

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4
Q

Castration responsive dermatosis?

A

CASTRATION-RESPONSIVE DERMATOSIS

Or hypogonadism of intact dogs’ “Dermatosis that responds to

castration”

Predisposed: Entire males; Pomeranian; Chow-chow; Malamute;

Husky

Clinical signs

§ Fine, “fluffy” coat § Hyperpigmentation

§ Symmetrical alopecia (neck; perineum; thighs)

Treatment: Castration

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5
Q

Hyperoestrogenism in females?

A

HYPEROESTROGENISM IN FEMALES

Predisposed: Middle/old-aged bitches

Aetiology: Cystic ovaries; Cystic tumours

Clinical signs

§ Symmetric alopecia § Seborrhoea

§ Generalised alopecia § Lichenification

§ Abnormal oestrus cycle § Enlarged vulva

§ Enlarged nipples

Treatment: Ovariohysterectomy & symptomatic treatment for seborrhoea

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6
Q

Oestrogen responsive dermatosis?

A

OESTROGEN-RESPONSIVE DERMATOSIS

In spayed females before first oestrous

Clinical signs

§ Symmetrical perineal alopecia § Puppy-like coat

§ Soft genital region § Small vulva

§ Small nipples

Treatment

§ None

§ Diethyl-stilbestro

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7
Q

Hypogonadism in intact females?

A

HYPOGONADISM IN INTACT FEMALES

↓ Functional activity of gonads

Predisposition: Poodle; Terrier; Dachshund

Primary hypogonadism: Infertility is treated early → No time for skin lesions to develop

Secondary hypogonadism: → Irregular cycle; Anoestrous

Noncyclic alopecia: <3 years old; Slow progression

Cyclic alopecia: Starts with oestrous → Recovery → May not

recover in time before anoestrous

Diagnosis is performed to exclude hypothyroidism & Cushing’s

Treatment: Spaying

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8
Q

Alopecia X ?

A

ALOPECIA X

Synonyms

§ “Hyposomatotropism”

§ “Sex hormone-responsive dermatosis”

§ “Castration-responsive dermatosis”

§ “Pseudo-Cushing’s”

May be caused by an abnormality of steroidogenesis (one or more diseases)

Predisposed: Young adults; All males; Spayed females; Poodles

Localisation: Everywhere except for the head & paws

Clinical signs

§ Hyperpigmentation § Scaling skin

§ Broken hair shafts § Dry skin

§ Alopecia § Thin skin

Diagnosis: ACTH-stim (measure adrenal gland hormones); Measure

sex hormones

Treatment

§ Castration/Spay

§ Melatonin

§ Trilostan

§ Mitotan

§ Testosterone

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9
Q

Other Conditions?

A

Other conditions

§ Hypothyroidism (see Topic 28)

§ Hyperadrenocorticism – Cushing’s (see Topic 30)

§ Diabetes mellitus (See Topic 27)

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