Immunity to Viruses Flashcards
What is the most important role of antibody in antiviral response?
neutralize the virus by binding to a portion of it needed for adsorption, penetration, uncoating, or replication
What portion of the virus does antibody neutralize?
external antigens
What are the most effective portions of the virus to neutralize?
Critical antigens
How might non-critical antigens also be effective at neutralizing?
by hindering part of the replication process/uncoating or introducing steric hindrance
Are neutralization reactions ever complete?
no
why are localized IgA responses important?
in the R, GI, GU tracts they act locally; enhanced in natural immunity or immunity to live attentuated viruses; neutralization response
Can antibodies lyse virions? Is it 100% efficient?
yes with the help of complement, no
What effect does the reaction of antibody or antibody plus complement have on immune clearance?
increases rate of uptake by phagocytes
when does CMI take over?
when virus infects cells
What response is mounted against virally infected cells?
cytotoxic T cell repsonse
What are interferons?
significant part of the immune response against viruses; produced by T cells in antigen dependent response
interferon gamma is the same as
macrophage activating factor
