Toxicology - Digoxin

Question 1

Acute Digoxin Toxicity - Presentation

Answer 1

NVD
headaches, confusion, delirium
visual changes
hyperkalemia

Question 2

Acute Digoxin Toxicity - EKG

Answer 2

prolonged PR interval

Question 3

Acute Digoxin Toxicity - Treatment

Answer 3

GI decontamination (activated charcoal)
digoxin-specific FAB fragments

Question 4

Acute Digoxin Toxicity - Treatment Indications

Answer 4

potassium > 5 mEq/L
digoxin level > 20 mcg/L
progressing signs of toxicity

Question 5

Acute Digoxin Toxicity - Digifab Dose

Answer 5

of vials = level x weight in kg / 100, round up

of vials = level of digoxin x weight in kg / 100, round up
if unknown -> 10 vials in adults & children

Question 6

Chronic Digoxin Toxicity - Presentation

Answer 6

no typical manifestation

Question 7

Chronic Digoxin Toxicity - Treatment Indications

Answer 7

post-distribution level of > 6 mcg/L
progressing or severe signs of toxicity

Question 8

Chronic Digoxin Toxicity - Digifab Dose

Answer 8

if unknown -> 5 vials in adults, 3 vials in children