Ipatropium (Atrovent)

Question 1

Class

Answer 1

Anticholinergic

Bronchodilator

Question 2

Description

Answer 2

Inhibits interaction of Ach @ receptor sites on bronchial smooth muscle, resulting in decreased levels of cyclic guanosine monophosphate & bronchodilation

Question 3

Onset & Duration

Answer 3

Onset: <15 minutes

Duration: >2-4 hours

Question 4

Indications

Answer 4

Persistent Bronchospasm

COPD exacerbation

Question 5

Contraindications

Answer 5

Hypersensitivity to:

Ipratropium
Atropine
Alkaloid
Soybean protein
Peanuts

Question 6

Adverse reactions

Answer 6

Nausea & vomiting
Cramps
Coughing
Worsening of symptoms
Headache
Tachycardia
Dry mouth
Blurred vision
Anxiety

Question 7

Drug interactions

Answer 7

None reported

Question 8

How supplied

Answer 8

MDI: 17 mcg/activation

Nebulizer solution: 0.02% (2.5 mL)

Question 9

Dosage & Administration (Adult)

Answer 9

0.5 mg nebulized; repeated twice. Nebulized ipratropium can be simultaneously administered w/ the first 3 doses of Albuterol or after the first dose of Albuterol. Can be administered as 1-2 inhalations via MDI

Question 10

Dosage & administration (Ped)

Answer 10

250-500 mcg (by nebulizer or MDI) q 20 minutes times 3 doses