Hyperlipidemia

Question 1

What drug class is artovostatin in?

Answer 1

Statins

Question 2

What is the action of statins?

Answer 2

Decrease LDL, VLDL, Triglycerides

Question 3

What is the pharmacokinetics of statins

Answer 3

First pass effect in liver, decrease drug bioavailability, metabolized by CYP450 enzymes

Question 4

Why do we give statins

Answer 4

CAD/CVD, stroke prevention

Question 5

What are the SE’s of statins?

Answer 5

Myopathies (muscle soreness due to rhabdomylosis,) hepatic dysfunction (elevated LFT’s,) N / constipation, HA, rash

Question 6

What pregnancy category - is statins?

Answer 6

X

Question 7

When do we ask our patients to take a statin? Why?

Answer 7

We ask them to takeit at night with evening meal because liver synthesizes cholesterol at night

Question 8

What drug class is fenofibrate?

Answer 8

Fibrates

Question 9

What is the action of fenofibrate?

Answer 9

Increase 02 to fatty acids to decrease hepatic production of triglycerides and VLDL

Question 10

Why do we give fenofibrate?

Answer 10

We give it to treat high triglycericles (hypertriglyceridemia)

Question 11

What are the SE’s of fenofibrate?

Answer 11

GI discomfort/D, gallstone formation

Question 12

What are the contraindications of fenofibrate?

Answer 12

Previous gallstone formation, hepatic/renal disease, cirrhosis, persistent liver function abnormalities

Question 13

What is the patient teaching of fenofibrate? Why?

Answer 13

We ask them to take with foodo because it increases absorption

Question 14

How long does it take for fibrates to reach therapeutic range?

Answer 14

1 month

Question 15

What enhances the effect of fibrates?

Answer 15

Warfarin

Question 16

What does niacin do?

Answer 16

Increases HDL?

Question 17

What drug class is niacin in?

Answer 17

Antilipemic agent

Question 18

What are the SE’s of niacin?

Answer 18

Shin flushing, hepatitis, hepatoxicity, hyperlipidemia, pruritis, gi irritation

Question 19

What increases the risk of hepatoxicity when administering Niacin?

Answer 19

Combination of niacin and statins

Question 20

What presents with metabolic syndrome

Answer 20

Central obesity, increased triglycerides, low HDL, hypertension and hyperglycemia when fasting

Question 21

What should cholesterol levels be at?
And what can affect each of them?
Tchol?
HDL?
LDL?
Trig?

Answer 21

Tchol <200
HDL >40 (healthy cholesterol, working out/genetics)
LDL <100/130 (bad cholesterol, genetics/diet change, red meat and carbs will raise it)
Trig <150 (sugar ETOH in blood)