regulation of and by PP1 (PP1c)

Question 1

PP1

Answer 1

diff from PP2A, has catalytic subunit that does a lot of the work, known as PP1c.

Question 1

PP1c does what

Answer 1

-Pi from ser/thr of m-GP-a, PhK’s apha and beta subunits which inactivates them and -Pi’s GS which activates it (breakdown and synthesis opposite)

Question 2

PP1c activation

Answer 2

only active when bound to another SU which is Gm subunit (muscle), important bc it is what you use to bind pp1c to actual glycogen particle.
and Liver pp1c only active when bound to glycogen via GL subunit

Question 3

PP1c reg differently in muscle and liver

Answer 3

via Gm (glycogen binding SU to pp1c) or GL subunit of PP1 complex… difference is GL not subject to +/-Pi control but Gm is.S

Question 4

Gm binds to which part of PP1C’s structure

Answer 4

Gm binds in a groove, parallel to B-14