Thymoma/thymic carcinoma

Question 1

masaoka staging of thymoma: TNM not preferred: Stage II

Answer 1

IIA: microscopic transcapsular invasion
IIB: macroscopic invasion into surrounding fatty tissue or grossly adherent to but not through mediastinal pleura or pericardium

Question 2

stage III masaoka

Answer 2

macroscopic invsion into neighbouring organs (pericardium, great vessels, lung)
A: without great vessel invasion
B: with invasion of great vessels

Question 3

Stage IV: masaoka

Answer 3

A: pleural or pericardial dissemination
B: lymphogenous or hematogenous metastasis.

Question 4

in few cancers staging system other than TNM is preferred

Answer 4

thymus
testicular

Question 5

Paraneoplastic syndrome associated with thymoma

Answer 5

myasthenia gravis
pure red cell aplasia
rheumatoid arthritis
scleroderma
addison disease
myocarditis

Question 6

hypertension may be caused by which of the mediastinal tumor

Answer 6

phemochromocytoma
chemodectoma
neuroblastoma
ganglioneuroma

Question 7

Differential diagnosis of anterior mediastinal mass

Answer 7

thymic tumors
thymomas
thymic carcinomas
thymic cysts
carcinoids
lymphomas
germ cell tumors: seminoma, non seminoma, CCA
parathyroid adenoma
lipoma .
liposarcomas

Question 8

D/D of middle mediastinal tumor

Answer 8

lymphomas
cysts
pericardial mass
thoracic duct
carcinoma
cardiac and pericardial tumor
lymphadenopathy
inflammatory

Question 9

posterior mediastinal mass

Answer 9

lymphomas
neurogenic tumor
peripheral nerve
schwannomas
neurosarcomas
neuroblastomas
paraganglia
mesenchymal tumors
endocrine tumor
esophageal tumor and cyst

Question 10

Radiation dose for thymic carcinoma/thymoma: unresectable disaese

Answer 10

60-70 gy

Question 11

radiation dose for thymoma: adjuvant

Answer 11

45-50 gy for clear/close margin
54 gy for microscopically positive margin
60-70gy for gross residual disease