Oral ulceration Flashcards

1
Q

causes of ulceration (5)

A
  1. trauma
  2. immunological (aphthous, lichen planus, lupus, vestibulo-bullous, erythema multiforme)
  3. carcinoma
  4. infections (any type)
  5. systemic - gastrointestinal (crohns, ulcerative colitis)
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2
Q

causes of single episode ulceraiton

A
  1. trauma (tooth brush, food, braces, restoration, biting etc)
  2. 1st episode of recurrent oral ulceration
  3. primary viral infecitons (coxsackie and herpes zoseter or simplex)
  4. squamous cell carcinoma
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3
Q

types of recurrent oral ulceration

A
  1. trauma if cause not removed (tooth brushing, braces, sharp tooth, restoration, biting, etc.)
  2. aphthous ulceration (3 types)
  3. erosive lichen planus
  4. vesiuculobullous lesions (4 types)
  5. recurrent viral lesions
  6. systemic disease (Crohns)
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4
Q

what are the types of recurrent aphthous stomatitis

A
  1. minor
  2. major
  3. herpetiform
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5
Q

types of vesiculobullous lesions

A
  1. pemphigus
  2. pemphigoid
  3. angina bullosa haemorrhagica
  4. erythema multiforme
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6
Q

what is the oral presentation of crohns

A
  1. crohs unique ulcers
    - linear at depth of sulcus for months
    - full of crohns associated granulomas
  2. aphthous type ulcers caused by haemotinic deficiency - behave like these ulcers
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7
Q

examination of oral ulceration main two points for diagnosis

A
  1. history of lesion/s
  2. description of lesion/s
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8
Q

how to do a history of blistering lesions?

A
  1. where
  2. size or shape
  3. how long for (individually / phases)
  4. recurrent (same or dif. place)
  5. painful
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9
Q

what to record on physical examination of ulcers

A

ABCs
1. Area
2. Border/margins (raised/rolled/flat)
3. Colour
4. surrounding tissue (inflammed?)
5. other - consistency (hard, rough, hard), number, VESICULATION?

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10
Q

what are the 3 main types of ulcers

A
  1. traumatic
  2. recurrent herpatic lesiosn
  3. recurrent apthous stomatitis
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11
Q

key diagnosis signs for recurrent herpetic lesions and what treatment

A
  1. lesions present along a common nerve branch i.e. MOSTLY one side of hard palate
  2. vesiculation prior to ulcer
  3. caused by herpes zoster or simplex (more likely if painful) or simplex
  4. treatment = SYSTEMIC aciclovir
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12
Q

what is the main rule and sign in diagnosing a ulcerative conditions

A
  • recurrent, self healing ulcers on NON-keratinised mucosa normally Aphthous
  • if on keratinised mucosa then most likely viral
  • if systemic ilness then most likely viral (coxsackie or herpes)
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13
Q

what is recurrent aphthous stomatitis

A
  • immunologically caused RECURRING ulcers
  • genetic basis with environmental modificiaiton
  • follow a specific ulceration pattern depending on which type
  • yellow fibre base of ulcer with erythematus halo
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14
Q

information on minor aphthous ulceration

A
  • <10mm
  • lasts <2 weeks / ulcer
  • ONLY non keratinised tissue
  • can have many
  • phase of ulceration can go away for a long or short time then environmental factor aggrivates and starts again
  • most common type of recurrent ucleraiton
  • react well to topical steroids
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15
Q

information on major aphthous ulcers

A
  • normally >10mm
  • can last for months
  • ANY oral tissue (non-keratinised/keratinised)
  • topical steroids rarely work (need intralesional)
  • can be diagnosed along side minor aphthous ulceration
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16
Q

what is herpetiform aphthae (herpetiform recurrent aphthous stomatitis) and what is its difference to primary herpatic gingivostomatitis and recurrent herpatic lesions

A
  • many SMALL ulcers - 2mm (can coalesce to make bigger)
  • on NON-keratinised tissue (dif. from herpetic lesions)
  • NOT caused by herpes (dif. to herpatic lesions)
  • …UNKNOWN cause
  • rarest form of aphthous ulcers
  • dif. from primary herpatic gingivostomatitis = PHG is on both keratinsied and non keratinised surfaces and PHG gives a fever most likely
17
Q

what is the aphthous ulceration disease that causes both oral and genital symptoms and give infomation on what this is, also what are the two criteria for diagnosing this

A
  • bahçets syndrom
  • inflammation of the blood vessels thus effects oter organs
  • to have this needs 2 of the following to be this disease - genital sores, eye inflammation, skin ulcers, pathergy
  • AND need 3 phases of ucleraiton in a year
  • difference from minor and major aphthous ucleration is that it is debilitating and will have out of the oral cavity consequences
  • linked to many other issues like with the heart and lungs, bowel ulceration, joints and the brain
18
Q

what are conditions that can effect the oral cavity and the genitals involving ulceraiton

A
  1. lichen lanus
  2. vesiculobullous diseases
  3. behçets syndrom
19
Q

environmental aggrivators of RAS

A
  1. pre menstral hormone fluctuations
  2. stress (main)
  3. sharp tooth
  4. nutrient deficiency (iron, B12, folic acid) - cause or a symptom
  5. viral and bacterial infections
20
Q

what is the mechanism that causes ulceration in apthae ulcers and what is the treatment for this

A
  • immunopathology at basal stem cells causing no new cells but shedding of other temporarily 3-4 days later
  • need to treat while immunological activity active (done in the 3-4 days)
  • patient can apply topical steroid if learn tingling sensaiton when occuring
  • or steroid mouthwash prophylaxis all the time
21
Q

tests when suspect an aphthous disease

A
  1. blood tests
    - haematinics (ferritin[iron], folic acid and b12)
    - coeliac disease - TTG
  2. NOT allergy tests, just take out diet and see if gets better
    - chocolate, e numbers (cinnamon, sorbette, benzoate[fizzy drinks])
    - test without eating these for 3 months and if benefit then connection
22
Q

aphthous treatment and managment

A
  1. tx
    - non-steroidal topical for inconvininet lesions
    - steroidal topical for disabling lesions
  2. managment
    - correct blood deficiencies
    - coeliac specialist
    - avoidance of dietary triggers
23
Q

describe the trends in RAS in children

A
  • tend to get ulcers and new shoes - at times of growth (less iron availability)
  • 8-11 and 13-16 yo
24
Q

specialist treatment for vesiculobullous

A
  1. prednisolone systemicly (steroid)
  2. azathiopine (immunosuppresant)
  3. micophenolate (immunosupressant)