Hematopoiesis

Question 1

1. The process of formation and development of blood cells is
   termed:
   a. Hematopoiesis
   b. Hematemesis
   c. Hematocytometry
   d. Hematorrhea

Answer 1

a. Hematopoiesis

Question 2

2. During the second trimester of fetal development, the primary site of blood cell production is the:
   a. Bone marrow
   b. Spleen
   c. Lymph nodes
   d. Liver

Answer 2

d. Liver

Question 3

3. Which one of the following organs is responsible for the
   maturation of T lymphocytes and regulation of their expression of CD4 and CD8?
   a. Spleen
   b. Liver
   c. Thymus
   d. Bone marrow

Answer 3

c. Thymus

Question 4

4. The best source of active bone marrow from a 20-year-old
   would be:
   a. Iliac crest
   b. Femur
   c. Distal radius
   d. Tibia

Answer 4

a. Iliac crest

Question 5

5. Physiologic programmed cell death is termed:
   a. Angiogenesis
   b. Apoptosis
   c. Aneurysm
   d. Apohematics

Answer 5

b. Apoptosis

Question 6

6. Which organ is the site of sequestration of platelets?
   a. Liver
   b. Thymus
   c. Spleen
   d. Bone marrow

Answer 6

c. Spleen

Question 7

7. Which one of the following morphologic changes occurs
   during normal blood cell maturation:
   a. Increase in cell diameter
   b. Development of cytoplasm basophilia
   c. Condensation of nuclear chromatin
   d. Appearance of nucleoli

Answer 7

c. Condensation of nuclear chromatin

Question 8

8. Which one of the following cells is a product of the common lymphoid progenitor (CLP)?
   a. Megakaryocyte
   b. T lymphocyte
   c. Erythrocyte
   d. Granulocyte

Answer 8

b. T lymphocyte

Question 9

9. What growth factor is produced in the kidneys and is used
   to treat anemia associated with kidney disease?
   a. EPO
   b. TPO
   c. G-CSF
   d. KIT ligand

Answer 9

a. EPO

Question 10

10. Which one of the following cytokines is required very early
    in the differentiation of a hematopoietic stem cell?
    a. IL-2
    b. IL-8
    c. EPO
    d. FLT3 ligand

Answer 10

d. FLT3 ligand

Question 11

11. When a patient has severe anemia and the bone marrow is
    unable to effectively produce red blood cells to meet the
    increased demand, one of the body’s responses is:
    a. Extramedullary hematopoiesis in the liver and spleen
    b. Decreased production of erythropoietin by the kidney
    c. Increased apoptosis of erythrocyte progenitor cells
    d. Increase the proportion of yellow marrow in the long
    bones

Answer 11

a. Extramedullary hematopoiesis in the liver and spleen

Question 12

12. Hematopoietic stem cells produce all lineages of blood
    cells in sufficient quantities over the lifetime of an individual because they:
    a. Are unipotent
    b. Have the ability of self-renewal by asymmetric division
    c. Are present in large numbers in the bone marrow niches
    d. Have a low mitotic potential in response to growth
    factors

Answer 12

b. Have the ability of self-renewal by asymmetric division