Blood - Circulatory System 1 Flashcards

1
Q

Composition of blood

A

55% plasma
45% cells suspended within

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2
Q

What does blood transport?

A
  • hormones (endocrines)
  • heat
  • antibodies
  • clotting factors
  • nutrients
  • excretory products
  • oxygen and carbon dioxide
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3
Q

Composition of plasma

A

90% water
10% dissolved substances

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4
Q

What are the dissolved substances?

A
  • plasma proteins
  • transported substances
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5
Q

What are the plasma proteins?

A
  • albumin
  • globulins
  • fibrinogen
  • prothrombin
  • serum
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6
Q

Albumin

A
  • Formed in liver
  • Helps maintain viscosity of blood – ensuring
    that the blood is not too thin and moving
    through vessels too quickly - therefore
    maintains blood pressure
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7
Q

Globulins

A
  • Formed in liver or lymphoid tissue
  • Produced during immune response
  • Transports hormones and minerals
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8
Q

Fibrinogen

A
  • produced in liver - necessary for haemostasis
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9
Q

Prothrombin

A
  • essential substance in blood coagulation
  • vitamin k is essential for its formation
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10
Q

Serum

A
  • plasma from which clotting factors have been removed
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11
Q

What are the transported substances

A
  • enzymes
  • hormones
  • nutrients
  • organic waste products
  • dissolved gases
  • dissolved inorganic salts
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12
Q

Enzymes

A
  • chemical substances which can produce or speed up changes in other substances
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13
Q

Hormones

A

Chemical substances from endocrine glands

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14
Q

Nutrients

A
  • amino acids
  • glucose
  • fatty acids
  • glycerol
  • vitamins
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15
Q

Organic waste products

A

Principally urea and uric acid

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16
Q

Dissolved gases

A
  • carbon dioxide
  • oxygen
  • nitrogen
17
Q

Dissolved inorganic salts

A
  • mainly sodium
  • potassium
  • calcium
  • chloride
  • bicarbonate

(Responsible for maintaining blood pH - 7.4)

18
Q

What are the blood cells?

A
  • erythrocytes
  • leucocytes
  • thrombocytes
19
Q

Erythrocytes/red blood cells

A
  • formed in red bone marrow
  • corpuscles - have no nucleus
  • biconcave discs - increases surface area for gas exchange, thinness in centre allows fast entry and exit of gases
  • main function - gas transport (mainly oxygen)
  • tend to clump together in groups (‘rouleaux formation’)
  • 5 million per cubic millilitre of blood
20
Q

Erythrocytes (2)

A
  • short life span - 120 days
  • development of erythrocytes known as erythropoesis
  • vitamin B12 necessary for erythrocyte maturation
  • ultimately destroyed in the spleen - haemolytic carried out by phagocytic cells
  • contain haemoglobin
  • An iron containing protein, concerned with oxygen transportation around the body
  • Iron released from Haemolysis is retained and reused to form haemoglobin
21
Q

Erythrocytes disorders?

A

ANAEMIA
- iron deficiency anaemia
- vitamin B12 deficiency anaemia
- sickle cell anaemia

22
Q

Thrombocytes

A
  • no true cell
  • no nucleus
  • fragments of larger bone marrow cells
  • important in blood clotting
  • 250,000 per cubic millilitre of blood
  • life span - 8-10 days
  • those not used in haemostasis - destroyed in spleen
  • Control of Thrombocyte production
    unclear but thought to increase if there is a decrease in circulating thrombocyte count
23
Q

Thrombocyte disorders

A

THROMBOCYTOPENIA
- reduced platelet production

CONGENITAL DISORDERS:
- haemophilia
- Von Willebrand’s disease