Tumor-Host interrelations Flashcards
may destroy vital structures due to their location and may even be fatal if benign, for instance, MENINGIOMA OF THE BRAIN
tumor masses
Local Effects
✓ Tumor masses (meningioma of the brain)
✓ obstruction in hollow organs (intestinal adenomas)
✓ ulcerations (cause thrombosis or infarction)
✓ observed clinical problems or cause necrosis
Systemic Effects
✓ cancer cachexia
✓ systemic reactions
✓ hormone production
✓ paraneoplastic syndromes
the wasting of body mass occuring out of proportion to the mass of neoplasm may be due to general inappetence resulting from the liberation of toxic products
cancer cachexia
cancer cachexia also;
✓ malabsorption
✓ increased metabolism
✓ chronic infection
this includes fever resulting from tissue necrosis and concomitant infection
systemic reactions
caused by progressive blood loss from ulcerated areas, and the weakening of the body’s natural resistance due to tumors products
anemia
some tumors retain their functional ability and secrete substances that may cause disease in the host
hormone production
functioning tumors of endocrine glands such as;
✓ adrenal cortex and medulla
✓ parathyroid
✓ pancreatic islets
are known to produce hormones in excess
pancreatic islets
some non-endocrine tumors produce ectopic hormone inappropriate for their tissue origin. when this happen, the clinical signs and symptoms cannot be explained by the presence of the local tumor
paraneoplastic syndromes
Some tumors causing paraneoplastic syndromes
✓ B-cell neoplasia
✓ multiple myeloma
✓ lymphoma
✓ anal gland carcinoma
✓ sertoli cell tumor
✓ pulmonary neoplasm
✓ mast cell tumor
✓ pancreatic B-cell neoplasia
✓ pituitary neoplasm
✓ adrenal tumor
