TRANSPLANTATION IMMUNOLOGY Flashcards
CLASS I PROTEINS:
HLA-A, B, C
CLASS II PROTEINS:
HLA-DRB1, HLA-DRA1, HLA – DQB1, HLA-DQA1, AND DPB1+DPA1
expressed on the cell surface covalently bound to beta-2- microglobulin.
CLASS I PROTEINS
expressed on virtually all nucleated cells.
CLASS I PROTEINS
expressed primarily on antigen-presenting cells
CLASS II PROTEINS
HLA proteins have critical roles for the development and functioning of the innate and adaptive immune systems.
CLASS II PROTEINS
Recognition elements for antigen receptors on T lymphocytes
CLASS II PROTEINS
Ligands for regulatory receptor on NK cells
CLASS II PROTEINS
HLA genes: causes an extensive degree of allelic polymorphism
CLASS II PROTEINS
While this has successfully enabled populations to survived infectious challenges, it severely restricts the ability to transplant foreign tissue or cells between any two individuals.
CLASS II PROTEINS
Restricts the ability to transplant foreign tissues or cells between any two individuals
CLASS II PROTEINS
It was identified based on outcomes studies in mice and humans demonstrating tissue rejection in MHC-identical transplants.
MINOR HISTOCOMPATIBILITY ANTIGENS
Based on outcomes of human stem cell transplants between HLA identical siblings in whom graft-versus-host disease has developed.
MINOR HISTOCOMPATIBILITY ANTIGENS
encodes a cell surface protein that is involved in gamma/delta T-cell responses.
MHC class I-related chain A (MICA)
are expressed on endothelial cells, keratinocytes, fibroblasts, epithelial cells, dendritic cells, and monocytes, but they are not expressed on T or B lymphocytes.
MIC proteins
