Clinical Perspective of Pulmonary Hypertension Flashcards
What population is most at risk for idiopathic pulmonary hypertension?
Young women of child bearing age
What calcium channel blocker is most utilized to treat pulmonary hypertension?
Nifedipine
When should IV vasodilators be considered for a patient?
A patient who experiences symptoms at rest and has significant impairment of daily activities and/or patients with RV dysfunction
Mutations of this gene are seen in nearly half of all familial cases of pulmonary hypertension.
Bone morphogenic protein receptor 2 (BMPR2)
This Group of pulmonary hypertension is due to unclear or multifactorial mechanisms.
Group 5
What is the MOA of Bosentan?
Endothelin-1 receptor antagonist
What is Group 1 pulmonary hypertension?
Pulmonary hypertension due to idiopathic, genetic, drug, or infectious causes.
A patient that develops pulmonary hypertension due to chronic small pulmonary emboli is considered what Group?
Group 4
What Group of pulmonary hypertension is due to lung diseases and hypoxia (ex: COPD, sleep apnea, interstitial lung disease)
Group 3
These hormones are innate vasodilators.
Prostacyclin, nitric oxide
What types of drugs may be utilized to treat Group 1 pulmonary hypertension?
Prostanoids, endothelin-1 receptor antagonists, PDE-5 inhibitors, calcium channel blockers, guanylate cyclase stimulators
What is the cause of Group 2 pulmonary hypertension?
Left heart disease
This histologic finding is a hallmark of Group 1 pulmonary hypertension.
Plexiform lesion
This drug is a PDE-5 inhibitor to treat pulmonary hypertension.
Sildenafil
This hormone acts as an innate vasoconstrictor.
Endothelin-1
