Pharmacology of Drugs Used for Lung Cancer

Question 1

This type of lung cancer responds best to traditional cancer drugs as it is fast-growing.

Answer 1

Small cell lung cancer

Question 2

What ADRs are associated with the lung cancer drug that inhibits the thymidylate kinase and dihydrofolate reductase?

Answer 2

Pemetrexed - low WBC, anemia

Question 3

What is the MOA of Pembrolizumab?

Answer 3

Binds to PD-1 receptor on T cells to destory cancer cells

Question 4

This cancer drugs acts by cross-linking DNA.

Answer 4

Cisplatin

Question 5

What cancer drugs are bone marrow sparing?

Answer 5

Cisplatin, bleomycin, vincristine

Question 6

Impaired wound healing is an ADR of this cancer drug.

Answer 6

Bevacizumab

Question 7

What is the MOA of pemetrexed?

Answer 7

Inhibits folate-dependent processes by inhibiting the thymidylate kinase and dihydrofolate reductase

Question 8

What is the MOA of gemcitabine?

Answer 8

DNA chain terminator

Question 9

What ADRs are associated with Paclitaxel?

Answer 9

Peripheral neuropathy, infusion reactions

Question 10

This cancer drug inhibits microtubule dissociation, blocking cell division in metaphase.

Answer 10

Paclitaxel

Question 11

What ADRs are associated with cisplatin?

Answer 11

Nephrotoxicity, ototoxicity

Question 12

This cancer drug is used in cancers that are EGFR positive.

Answer 12

Osimertibin - irreversible inhibitor of EGFR tyrosine kinase

Question 13

What is the MOA of Bevacizumab?

Answer 13

Inhibits VEGF binding to prevent angiogenesis

Question 14

What therapies must be co-administered with pemetrexed?

Answer 14

Folic acid & B12