15&17 - Chronic Diseases Flashcards
(37 cards)
What is the test in lower limb ischaemia?
- Buerger’s Test
- Elevate leg to 30 degress for 30-60 seconds
- Observe any colour change
- Colour change below 20 degrees indicates severe ischaemia
- Slow return of colour, or blueness indicates hyperaemia
CKD
- Seven medications groups?
- ACEi (protective)
- SGLT2
- Atorvastatin 20mg (CHD)
- Vit D/Colecalciferol
- EPO
- RRT
- Vaccination
CKD
- Six safety-net flags?
- Oliguria
- Flank pain
- Pruritis
- Muscle pains
- Oedema
- Palpitations
What are the sick day rules for CKD and what qualifies?
- When vommitting and/or diarrhoea
2. Stop ACEi, NSAIDs, Diuretics
What investigations are indicated in HTN for organ end-damage?
- Fundoscopy
- eGFR
- Bloods and ECG
HTN
- Three main drug groups
- ACEi/ARB
- CCB
- Thiazide-like diuretics
What safety-netting is indicated in HTN?
- Visual disturbance
- Sensory change
- BP > 180/90
What is the criteria for Hyperlipidaemia?
- Total Cholesterol >5.18mmol/L
- LDL cholesterol > 2.49mmol/L
- HDL cholesterol <1.04 mmol/L
- Triglycerides > 1.7mmol/L
Six hyperlipidaemia management options?
- Lifestyle modification
- 10% QRISK - Moderate intensity statin
Atorvastatin 20mg - High risk of ASCVD (atherosclerotic cardiovascular disease)
Atorvastatin 40-80mg - LDL-cholesterol remains >1.8mmol/L
Ezetimibe 10mg PO - LDL-c remains >1.8 at step 4
Alirocumab 75-150mg (PCSK9 inhibitor - prevents LDLR antagonism) - LDL-c >4.9 without DM and <75yo
Colestyramine 4g PO (bile acid sequestrant)
Followup from commencing statin therapy?
- 3 Month lipid profile
- Aim for 40% reduction
- Check CK levels
- Watch for muscle pain
Tests for DM
- HbA1c
- Fasting glucose
- Fructosamine
- OGTT
DM 9 Processes of Care
- Screen before
Retinopathy
Peripheral vascular
Albuminuria - Lifestyle now
Smoking
BMI
BP - Monitor later
Lipids
HbA1c
Creatinine
Statin Dosing in DM
QRISK >10%
Primary prevention - 20mg Atorvastatin
Secondary prevention - 80mg Atorvastatin + 75mg Aspirin
DM with microvascular changes/microalbuminuria
- BP Target
DM target with changes:
- 130/80
DM Drugs and Targets
Metformin 500-2000mg
Liver
Muscles
- Gliclazide 40-320mg
Pancreatic insulin (NB Hypos)
Very potent - not for elderly - GLP-1 eg Semaglutide 0.25-1mg once weekly
Pancreatic action - DPP-4
Indirect/mild impact
Sitagliptin 100mg oD
Linagliptin
How to test the reversibility of a pulmonary disorder?
- Baseline spirometry
- Bronchodilation
- Salbutamol (2 x 200mcg puffs)
- Large volume spacer
- Salbutamol (2 x 200mcg puffs)
- Pause for 30 minutes
- Repeat spirometry
- FEV/FVC ration
Example SABA inhalers?
- Salbutamol MDI (100mcg)
- Ventolin
- Salamol
- Airomir
- Salbutamol DPI (200mcg)
- Ventolin
- Terbutaline (500mcg)
- Bricanyl
ICS MDIs
ICS MDIs
- Clenil modulite
- 50mcg Beclometasone
- QVAR
- 50mcg Beclometasone
- Flixotide
- 50 mcg Fluticasone
ICS/LABAs
ICS/LABAs
- Seretide 250
- 250mcg Fluticasone
- 25mcg Salmeterol
- Symbicort 200
- 200mcg Budesonide
- 6 mcg Formoterol
- Fostair 200
- 200mcg Beclometasone
- 6 mcg Formoterol
LABAs
Serevent MDI
- Salmeterol 25 mcg
Serevent Accuhaler
- Salmeterol 50 mcg
Formoterol Easyhaler
- 12 mcg formoterol
Oxis 6 turbohaler
- 6mcg formoterol
LAMAs
LAMAs
- Spiriva Respimat SMI (soft mist)
- 2.5 mcg Tiotropium bromide
- Spiriva MDI
- 18 mcg Tiotropium Bromide
Spacers
- Advantages
- Designs
Spacers
- Pros
- Waste less
- Fewer ADRs
- Designs
- Volumatic
- Aerochamber
Asthma Prevention Plan
Three key components
Asthma Prevention Plan
- Everyday
- Exacerbation
- Attack
Asthma Prevention Plan
- Everyday
- Everyday Asthma Prevention
- Preventer inhaler regime
- Reliever inhaler regime
- Others