Flashcards in 15 Consideration with HIV Combination Louie Deck (14)
What is the DHHS recommended NNRTI based regimen?
What is the DHHS recommended Boosted PI based regimen?
ATV/r + TDF/FTC. OR. DRV/r + TDF/FTC
What is the DHHS recommended II based regimen?
RAL + TDF/FTC
Which drug should be avoided in pregnancy?
Which drug needs HLA-B*5701 testing and why?
ABC. Hypersensitivity reaction
What are the most favorable patients for NNRTIs?
Want maximum simplicity (1 pill QD). Concerns about renal function (when combined w/ TDF/FTC)
If someone has a job that requires concentration, what should be avoided?
EFV. CNS effects
Which NNRTI isn't recommended for irregular meals?
Which NNRTI isn't recommended with PPIs or H2 blockers?
In the study comparing three different treatment options, which one showed the best results?
EFV + 2 NRTIs > LPV/r + 2 NRTIs, EFV + LPV/r
What patients are more favored for the Boosted PI based regimen?
Prefer not to deal with CNS ADRs. Might become pregnant. Prefer once-daily dosing
When is the Boosted PI based regimen less favorable?
Diabetes. Hyperlipidemia at baseline. Concerns about renal function. Taking other drugs metabolized by CYP system. Might have an issue with potential or jaundice or scleral icterus (ATV)
When is the II based regimen preferred?
Maximum simplicity (EVG). Prefer not to deal w/ ADRs associated w/ other regimens. Need concomitant drugs w/ interactions with other antiretrovirals (RAL). Concerns about CV risk. Do not mind BID dosing (RAL)