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Bioleg > 1.5 Nucleic Acids And Their Functions > Flashcards

1.5 Nucleic Acids And Their Functions Flashcards

1
Q

What is the definition of translation

A

Changing the words of one language into the words in another language that have the same meaning

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2
Q

What is the two stages of protein synthesis

A

Transcription and translation

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3
Q

What is translation

A

The process that changes the coded information of mRNA into the correct sequence of amino acids, forming a polypeptide

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4
Q

What’s the function of tRNA

A

To carry amino acids to the ribosomes

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5
Q

What is amino acid activation

A

The attachment of an amino acid to its transfer RNA (tRNA)

The tRNA attaches to a specific amino acid in the presence of an enzyme and ATP (requires energy)

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6
Q

3 functions of tRNA

A
  1. tRNA’s carry specific proteins
  2. The tRNA cannot pick up an amino acid unless the amino acid is activated
  3. The amino acid attachment site of a tRNA will bind to a specific amino acid, if energy is supplied
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7
Q

What is translation step one (name and what is it )

A

Step one is initiation

The mRNA molecule with the START CODON AUG attaches itself to the ribosome. Most polypeptide chains start with AUG which codes for the amino acid methionine

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8
Q

What is translation step two

A

The tRNA, with and anticodon complementary to the first codon on the mRNA, attaches itself to the ribosome
Hydrogen bonds bind to the three bases of the codon on the mRNA to the complementary bases of the anticodon in the tRNA

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9
Q

Translation step three

A

A second tRNA molecule attaches to the ribosome. It has an anticodon complementary to the second codon on the mRNA

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10
Q

Translation step four

A

Elongation

The amino acids attached to the two tRNA molecules are close enough for a peptide bond to form between them. A ribosomal enzyme catalyses the formation of this bond.
The first tRNA leaves the ribosome leaving its attachment site empty.

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11
Q

Translation step 5

A

The ribosome moves one codon along the mRNA strand
The second tRNA molecule now occupies the first attachment site. Leaving the second site free
A third comes to fill this site and a peptide bond forms between the second and third amino acid

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12
Q

Translation step six

A

The ribosome moves along the mRNA stand reading off the message a codon at a time.
As it moves, more tRNA’s attach to the ribosome bringing their animo acids.
The polypeptide chain grows

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13
Q

Translation step seven

A

Termination

This continues until a stop codon occurs in the mRNA. These donor code for amino acids
The mRNA separates from the ribosome and the completed polypeptide chain is released to the cytoplasm

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14
Q

One gene one polypeptide hypothesis

A

1940s radiation damage to DNA prevented a single enzyme from being made. This led to one gene one enzyme hypothesis

Enzymes are proteins so became one gene one protein hypothesis

Some proteins like haemoglobin consist of more then one polypeptide so it let to one gene one polypeptide hypothesis

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15
Q

Define a gene

A

A gene is a sequence of DNA bases that codes for a polypeptide

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16
Q

What is post translation modification

A

Polypeptides that made on ribosomes carry through the cytoplasm to Golgi body. In the Golgi the polypeptide is folded into secondary, tertiary or quaternary structures

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17
Q

What is a haemoglobin / how is it made

A

Folded tertiary structure
Combines with non protein groups
Four polypeptides are combined (quaternary = 4)
Alpha helix regions (secondary structure)

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18
Q

Definition of transcription

A

An exact written copy of something

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19
Q

What carries the information to build a protein from amino acids

A

Dna carries the information to build the amino acids

DNA doesn’t leave the nucleus

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20
Q

What is immense involved in carrying

A

The genetic code from DNA in nucleus to the ribosomes in the cytoplasm where protein is made

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21
Q

Function of ribosomes

A

Site of protein synthesis

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22
Q

What 3 parts make up each nucleotide

A

A phosphate group
A Penrose sugar
A base which contains nitrogen

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23
Q

What is a cistron

A

The cistron is a length of DNA that forms a mRNA molecule. A cistron is often equivalent to a gene and codes for a specific polypeptide

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24
Q

Step one of transcription

A

DNA unwinds as the hydrogen bonds between the base pairs ar broken by the enzyme DNA helicase

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25
Step two of transcription
One of the two DNA strands acts as a template against which a matching RNA strand is formed. RNA nucleotides are attracted to complementary bases on the DNA strand.
26
Step 3 of transcription
The enzyme RNA polymerase binds to the template strand of DNA at the beginning of the sequence to he copied. The enzyme moves along the DNA forming bonds that add nucleotides one at a time to the RNA strand
27
Step 3 of transcription
The enzyme RNA polymerase binds to the template strand of DNA at the beginning of the sequence to he copied. The enzyme moves along the DNA forming bonds that add nucleotides one at a time to the RNA strand
28
Step 4 of transcription
RNA polymerase separates from the DNA strand when it reaches a 'stop' signal. The transcript is complete and the newly formed RNA detaches from the DNA
29
What are extrons
Parts of dna that do code for proteins
30
What are introns
Non coding regions of a gene - these sequences don't actually code for a protein
31
What are the two different types of sequences in a gene
Introns and exons
32
What is the two types of nucleus acids
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA)
33
Define polymers
A long chains of repeating units made up of nucleotides
34
What 5 carbon Penrose sugar is in dna
Deoxyribose
35
What 5 carbon pentode sugar is in rna
Ribose
36
What are the 5 types of bases
Adednin Thymin Gwanin Cytosin And uracil is only present in rna
37
What is the three bases with a single ring structure and the name for this
Cytosine, thymine and uracil They are called pyrimidines One way of reminding is based with second letter is 'y' and uracil are pyrimidines
38
What are the two bases with a double ring structure and the name of this
Adenine and guanine They are called purines
39
What does uracil replace in rna
Urscilbreplaces thymine
40
What reactions breaks hydrogen bonds
Condensation reaction
41
What do hydrogen bonds hold together
Between the sugur and the phosphate group
42
What are the rules of base pairing
1. Always pair the same way - adenine and thymine - cytosine with guanine 2. Bases are held together by hydrogen bonds - 2 hydrogen bonds hold adenine and thymine together - 3 hydrogen bonds hold cytosine to guanine
43
What is a double helix
Two polypeptide chains twisted into a helix
44
What are the two functions of dna
Replication and protein synthesis
45
Why is dna suited to its functions
1. Very stable molecule 2. Large molecule 3. Strands are able to separate 4. Base pairs are on the inside of the double helix which means genetic information is protected
46
What are the three types of RNA
1. Messenger RNA (mRNA) 2. Ribosomal RNA (rRNA) 3. Transfer RNA (tRNA)
47
What is the functions of mRNA
1. Long single stranded molecule 2. Manufactured in the nucleus 3. Carries the genetic code from the DNA to the ribosomes in the cytoplasm 4. Lengths vary
48
What are the functions of rRNA
1. Found in the cytoplasm 2. Ribosomes are made up of ribosomal RNA and protein - they are the site of translation of the genetic code into protein
49
What are the functions of tRNA
1. Small and single stranded molecule 2. Base sequence c-c-a to which amino acid it carries is attached 3. Sequence of 3 bases called and anticodon 4. tRNA bring amino acids to the ribosome so that proteins can be synthesised
50
Functions of DNA
1. Double stranded 2. Penrose sugar is deoxyribose 3. Organic bases present are adenine, guanine, cytosine and thymine 4. Found in nucleus 5. Permanent 6. One basic form
51
What are the functions of RNA
1.single stranded 2. Penrose sugar is ribose 3. Organic bases present are adenine, guanine, cytosine and uracil 4. Made in nucleus but found throughout cell 5. May be temporary- existing for short periods only 6. Three basic forms: messenger , transfer and ribosomal RNA
52
What are the two major functions of DNA
Replication and protein synthesis
53
What is DNA
DNA is a molecule that carries instructions for the construction and behaviour of cells
54
Why do chromosomes make copies of themselves
1. The new cells formed at cell division have all of the correct genetic 2. The genetic information can be passed on to the offspring in the sperm and the egg
55
What's the first step of dna replication
The hydrogen bonds between the bases break. DNA unwinds and the two halves of the molecule separate. This is catalysed by the enzyme helicase
56
What happens in the second stage of DNA replication
As the DNA unwinds, the bases are exposed. Therefore each half of the molecule acts as a template on which a new strand of DNA can be built
57
What is stage 3 of DNA replication
Free nucleotides attach to each template DNA according to the law of base pairing. The enzyme DNA polymerase catalyses the condensation reactions between the nucleotides
58
What is semi conservative replication
The original double helix separates into two strands. Each of which then acts as a template for the synthesis of a new strand
59
What is conservative replication
The original double helix remains intact and a completely new double helix is made
60
What is dispersive replication
The two new double helices contain fragments from both strands of the original double helix
61
What is the evidence of the semi conservative hypothesis
- Called ultracentrifugation - the process spins liquid -most dense molecules are forced to bottom of the tube - less dense particales found at top of tube
62
What 4 things should you keep the same during the process ?
1. Speed 2. Time spinning 3. Density / concentration of gel 4. Temperature
63
What are genes
Genes are small sections of DNA
64
What are chromosomes made up of
Made of long, coiled strands of DNA
65
What is the information that the gene carries called ?
Genetic information
66
How many bases code for one amino acids
3
67
What is the structure of RNA nucleotides
One phosphate group One ribose Penrose sugar One nitrogenous base
68
What is the structure of ATP nucleotides
One adenine base One ribose Penrose sugar Three phosphate groups
69
What is the structure of DNA nucleotides
One phosphate group One deoxyribose Penrose sugar One nitrogenous base
70
What molecule makes the energy available when it is needed is ?
ATP
71
How many kg of ATP do we make and break down each day ?
50kg
72
Is ATP an energy store ?
No, our body contains about 5G of ATP therefore isn't a energy store
73
Hydrolysis by ATPase
- ATPase breaks the bond between the second and third phosphate - removing the third phosphate group - H2O adds - is a reversible reaction - needs 30.6KJmol-1 - Endergonic reaction
74
What are the advantages of atp
1. Energy released quickly - one step reaction 2. Involves one enzyme 3. Energy released in small amounts 30.6KJ 4. Is the universal energy currency 5. Common source of energy in all living things
75
Uses of ATP
1. Used in anabolic reactions 2. Active transport 3. Muscle contraction 4. Nerve impulse transmission

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