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CVS II Drugs Used in Angina Pectoris > Anticoagulant Treatment > Flashcards

Anticoagulant Treatment Flashcards

1
Q

What is Heparin MOA

A

Activates antithrombin, which decrease action of IIa(thrombin) and factor Xa short half life

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2
Q

What is the clinical use of heparin

A

PE
Acute Coronary syndrome
MI
DVT
Pregnancy don’t cross placenta

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3
Q

What is the side effect of heparin

A

HIT
Bleeding

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4
Q

For rapid reversal of heparin what is the antidote

A

Protamine sulfate

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5
Q

Name direct thrombin inhibitors

A
  1. Bivalirudin
  2. Argatroban
  3. Dabigatran only oral agent
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6
Q

What is the MOA of Dabigatran?

A

Directly inhibits activity of free and clot associated thrombin

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7
Q

What is the clinical use of Bivalirudin?

A

Atrial fib
Venous thromboembolism
HIT
Does not require lab monitoring

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8
Q

What is the side effect of Argatroban

A

Bleeding

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9
Q

Dabigatran can be reverse with

A

Idarucizumab

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10
Q

What is the MOA of warfarin

A

Inhibits epoxide reductase, which interferes with gamma carboxylation of Vit K-dependent clotting factors II,VII,IX,X and Proteins C & S

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11
Q

In laboratory assay what labs would you order for warfarin

A

PT/INR
PT would be increase
Extrinsic pathway

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12
Q

What is the clinical use of warfarin

A

Thromboembolism prophylaxis
Prevent of stroke in atrial fib
Chronic anti coagulation
Not use in pregnant

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13
Q

What labs will you order for your patient on warfarin

A

PT/INR

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14
Q

What is the side effects of warfarin

A

Teratogenic
Bleeding
Skin/tissue necrosis

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15
Q

For the reversal for warfarin

A

Vit K, FFP or PCC

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16
Q

What are the names of the Direct factor Xa inhibitors

A

ApiXaban, rivaroXaban

17
Q

What are the MOA of Apixaban

A

Binds to and directly inhibits factor Xa

18
Q

What is the clinical use of Factor Xa inhibitor

A

Tx and prophylaxis for DVT and PE
Stroke prophylaxis in pt with atrial fib

19
Q

What are the side effect of Apixaban, rivaroxabon

A

Bleeding

20
Q

What are the MOA of Clopidogrel, prasugrel, ticagrelor, ticlopidine

A

Inhibits platelet clotting by irreversible blocking ADP(P2Y12) prevent expression of IIb/IIIa

21
Q

What is ADP inhibitors Clinical use

A

Acute coronary syndrome
Coronary stenting

22
Q

What is the side effect of clopidogel

A

Neutropenia

23
Q

What is the name of this drug. It MOA is increase cAMP in platelets, resulting in inhibition of platelet aggregation and VD

A

Antiplatelet phosphodiesterase inhibitors
1. Cilostazol
2. Dipyridamole

24
Q

What is the side effect of PDE5?

A

Nausea
H/A
Flushing
Hypotension

25
Q

What is Abciximab S/E,MOA, and clinical usage

A

1.Bleeding & thromocyopenia is side effect
2. Use in unstable angina and PCI
3. Binds to the IIb/IIIa on platelets preventing clotting
4. Eptifibatide
5. Tirofiban

CVS II Drugs Used in Angina Pectoris (18 decks)

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