Prematurity And Rubella Flashcards
also known as “German Measles
CRS
Crs is characterized by:
○ Maculopapular rash
○ Lymphadenopathy
○ Fever
CRS Defects are often rare when the infection occurs in the
20th week or after the 20th week of gestation.
If infection occurs 0-28 days before conception
the infant has a 43% chance of being a ected
If the infection occurs 0-12 weeks after conception
the chance increases to 51%
If the infection occurs 13-26 weeks after conception
the chance is 23%
Infants are not generally a ected if rubella is contracted during
The 3rd trimester
Gestational age: 1-8 weeks
Cardiac defect (heart) and hearing impairment, other CRS anomalies (80%)
Gestational age: 9-12 weeks
Hearing impairment and features of CRS (50%)
Gestational age: 13-16 weeks
CRS anomalies (30%), hearing loss is prominent than other features.
Chances of fetal damage are minimal or none
> 20 weeks
Rubella immunoglobulin M (IgM) antibody detected
infants < 6 months old
Sustained rubella immunoglobulin G (IgG) antibody level detected in serum;
present on at least two occasions between 6 and 12 months of age
Any infant < 12 months with suspicion of CRS. The following clinical manifestation should lead to suspicion of CRS:
(1) Congenital heart disease and/or
(2) suspicion of hearing impairment; and/or one or more of the following eye signs: (a) cataract; (b) congenital glaucoma; or (c) pigmentary retinopathy (salt and pepper).
An infant of < 12 months in whom a qualified clinician detects:
At least two of the complications listed in group A or one in Group A and one in group B:
Cataract(s), congenital glaucoma, congenital heart disease, hearing impairment, pigmentary retinopathy
Group A
Purpura, splenomegaly, microcephaly, meningoencephalitis, radiolucent bone disease, jaundi
Group B
An infant who is a suspected case with one condition from Group A and meets laboratory criteria for CRS
Lab confirmed CRS
An infant who does not have group A clinical signs of CRS but who meets the laboratory criteria for CRS is classified as having congenital rubella
CRI
Auditory defect of CRS
sensorineural hearing impairment
Neurologic impairment of CRS
○ Microcephaly
○ Cerebral calcifications
○ Meningoencephalitis
○ Behavioral disorders, mental retardation
Neonatal manifestations of CRS
○ Low birth weight
○ Interstitial pneumonitis
A birth defect where a baby’s head is smaller than expected when compared to babies of the same sex and age.
Microcephaly
There are calcium deposits in the brain and the e ects of that vary depending on the severity and area of the calcification
Cerebral calcifications