Renal tubular reabsorption and secretion

Question 1

Define primary vs secondary active transport

Question 2

What’s the main function of the proximal tubule?

Question 3

What’s the main function of the descending loop of Henle?

Question 4

What’s the main function of the thin ascending loop of Henle?

Question 5

What’s the main function of the thick ascending loop of Henle?

Question 6

Where is water most permeable in the Loop of Henle?

Question 7

Where does thiazide diuretics act on?

Question 8

Where does furosemide act on?

Question 9

Where is the location of the ascending/descending loop of Henle?

Question 10

What’s the water permeability in the early portion of the distal tubule?

Question 11

What’s the MOA of ADH?

Question 12

What are the 2 main cell types found in the distal tubules/ collecting duct and their functions?

Question 13

Urea is reabsorbed by passive diffusion as it follows osmosis of water - how can it still be secreted in urine?

Question 14

Where is the juxtaglomerular complex located? What’s its function?

Question 15

Where does K+ sparing diuretics act on?

Question 16

What are the 2 types of intercalated cells and their functions?

Question 17

How is the function of the principal cells regulated?

Answer 17

aldosterone

Question 18

What are the 3 main functions of the medullary collecting duct?

Question 19

Where do Na+ channel blockers work?

Answer 19

fig 28-12

Question 20

What are the 2 primary forces that determine the peritubular capillary reabsorption?

Question 21

What are the 2 determinants of peritubular capillary hydrostatic pressures?

Question 22

What are the 2 determinants of peritubular capillary oncotic pressures?

Question 23

How does increased arterial blood pressure influence reabsorption rate (3 main mechanisms)?

Question 24

How does increased filtration fraction influence reabsorption rate?

Answer 24

H

Question 25

How does Addison’s effect sodium and potassium levels in the body?

Question 26

What is the most powerful Na+ retention hormone in the body?

Question 27

What are the 3 mechanisms of Na+ retention action of Angiotensin II?

Question 28

What are the 5 hormones that regulate tubular reabsorption?

Answer 28

table 28-3