Dialysis Flashcards

1
Q

what is dialysis

A

mimics the glomerulus ultra-filtration by removing fluid by hydrostatic pressure or osmotic gradient
mimics the proximal/distal tubule for reabsorption and conservation of wanted molecules

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2
Q

when is dialysis indicated

A

end stage
eGFR average is 7ml/min
unmanageable by other interventions
severe symptoms

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3
Q

what are the severe symptoms of end stage CKD

A

fatigue
N&V
itchy
drowsy
bone pain
inability to urinate
weight loss

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4
Q

what are the two types of dialysis

A

haemodialysis and peritoneal dialysis

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5
Q

what is haemodialysis

A

artificial kidney - uses a filter and semi permeable membrane to clean blood and return to the body

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6
Q

what is peritoneal dialysis

A

Patients own peritoneum acts to mimic the glomerular basement membrane - rich in blood supply and creates an empty space
- Dialysate fluid runs into cavity by gravity
- Fluid then drained out under gravity when full and new bag is put in
4 exchanges a day everyday - can be done at home

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7
Q

what access is required for haemodialysis

A

arteriovenous fistula is gold standard
- joined artery and vein to form large vessels

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8
Q

what access is required for peritoneal dialysis

A

Tenckhoff catheter through abdominal wall and sits in cavity

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9
Q

what are the two types of peritoneal dialysis

A

continuous ambulatory peritoneal
- 4 x a day every day at home
automated peritoneal dialysis
- carried out by a machine overnight
- reduced infection risk and improved adequacy

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10
Q

what is the adequacy of haemodialysis

A

work up to 3-5hr sessions to prevent disequilibrium syndrome
x 3 week
tolerance - may cause dizziness/hypotension

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11
Q

what are the symptoms of disequilibrium syndrome

A

headaches
N&V
convulsions in large urea removal

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12
Q

what are the advantages to peritoneal dialysis

A
  • reduced anaemia risk less blood lost
  • less aggressive
  • better for cardiac stability
  • can be done at home
  • dietary and fluid restriction not as strict
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13
Q

what are the disadvantages of peritoneal dialysis

A
  • peritonitis risk
  • membrane can become fibrosed
  • hypoglycaemia risk
  • requires a lot of equipment
  • less clearance of smaller molecules
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14
Q

what are the diet and fluid requirements for dialysis patients

A

healthy diet
low potassium
low phosphate
high protein in CAPD
urine output + 500ml/750ml in HD/PD

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15
Q

what medication considerations need to be made in dialysis

A

fluid management - stop diuretics
acid/base balance - stop bicarbonate
hypertension - monitor - likely to reduce post dialysis
renal bone disease - remain on treatment
erythropoietin - increased blood loss risk so continue

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16
Q

what drug factors increase risk of removal in dialysis

A

low MW
low plasma protein binding
low VD
high water solubility
high renal clearance

17
Q

dialysis factors that increase drug removal

A

membrane type in HD
dialysis duration
fluid composition
peritoneum pathology
blood flow rate (HD)