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Renal and Endocrine > 1.5.2 Glomerular Disease Part 1 > Flashcards

1.5.2 Glomerular Disease Part 1 Flashcards

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1
Q

What is this an image of?

A

Normal glomerulus

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2
Q

What are the characteristics of Henoch-Schonlein purpura?

A

It is morphologically indistinguishable from IgAN

Presents with systemic vasculitis

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3
Q

What are the features of secondary IgA nephropathy?

A

Associated with GI disease - espcially cirrhosis

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4
Q

What is this an image of?

A

Mesangial matrix expansion

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5
Q

p-ANCA is associated with?

A

MPA and Churg-Strauss

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6
Q

What will an IF image show in goodpastures?

A

IgG depositions on the glomerular basement membrane

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7
Q

What are the whited out figures?

A
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8
Q

What are the EM findings associated with with post-infectious glomerulonephritis?

A

Subepithelial humps

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9
Q

What is this an image of?

A

Nodular mesangial expansion

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10
Q

What are the arrows pointing at?

A

Sub-epithelial humps associated with with post-infectious glomerulonephritis

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11
Q

What is this an image of?

A

Tubuloreticular inclusion

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12
Q

What is this an image of?

A

post-infectious glomerulonephritis

notice high levels of neutrophils

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13
Q

What are the characteristics of accelerated hypertensive kidney disease?

A
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14
Q

What are IF findings associated with with post-infectious glomerulonephritis?

A

C3 depositions

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15
Q

What is this an image of?

A

IF image of C3 deposition with with post-infectious glomerulonephritis

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16
Q

What is this an image of?

A

Diffuse Lupus Nephritis (Class IV)

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17
Q

What is this an image of?

A

Arterial wall destruction due to ANCA associated renal dz

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18
Q

What is this an image of?

A

Scarring/sclerosis of glomeruli

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19
Q

What is this an image of?

A

Focal Lupus Nephritis (Type 3)

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20
Q

What is this an image of?

A

Sclerosis/scarring - hyaline deposits

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21
Q

What is this an image of?

A

Mesangial proliferation associated with IgA nephropathy

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22
Q

What is this an image of?

A

Mesangial hypercellularity

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23
Q

What is this an image of?

Study These Flashcards
A

Thin basement membrance dz

24
Q

What is this an image of?

Study These Flashcards
A

Endocapillary hypercellularity

25
What are double contours?
These are typically a result of endothelial/subendothelial injury. Endothelial cells make new basement membrane.
26
What is this an image of?
Extrinsic hypercellularity - crescents
27
What is this an image of?
Crescent shaping - goodpastures
28
What are the clinical features of primary IgA nephropathy?
Recurrent hematuria associated with simultaneous upper respiratory infection
29
What are the characteristics of ANCA-associated GN?
30
What are the characteristics of thin basement membrane syndrome?
31
What is this an image of?
GBM associatied with IgA nephropathy
32
What is this?
Glomerular anatomy
33
What is this an image of?
Capillary thrombi associated with accelerated hypertensive kidney disease
34
What is this an image of?
Alport syndrome
35
What are some causes of mesangial matrix expansion?
DM or HTN Ig or Ig complex deposition
36
What is this an image?
Lupus Nephritis (Immune complex deposition)
37
38
What is this an image of?
IgA deposition associated with IgA nephropathy
39
What are the clinical features of nephritis?
Hematuria Mild-moderate proteinuria HTN Active urine sediment
40
What is this an image of?
Glomerular capillary thrombosis
41
What are the characteristic pathological findings associated with SLE?
42
What does segmental vs global mean when describing a glomerulus?
Segmental - involving parts of a glomerulus Global - involving the entire glomerulus
43
What is this an image of?
Crescent shaping associated with ANCA nephritis
44
c-ANCA is associated with?
Wegener's
45
What are the key features of Goodpasture's Disease?
46
What are these images of?
Active urine sedimentation associated with nephritis
47
What are the main clinical features of nephrotic syndrome?
Proteinuria Hypoalbuminemia Edema Hyperlipidemia
48
What is this an image of?
Accelerated hypertensive kidney disease
49
What are the pathological characteristics of primary IgA nephropathy?
Mesangial expansion/cellular proliferation IgA
50
What is this an image of?
Structured deposits - fibrillar
51
What are the clinical features of post-infectious streptococcal glomerulonephritis?
Hypocomplementemia Post infection with Group A Strep **Delay in symptoms - 1 to 2 weeks**
52
What these image of?
53
What is this an image of?
Onion skin appearance of accelerated hypertensive kidney disease
54
What is this an image of?
Double contours
55
What are the light microscopy findings with post-infectious glomerulonephritis?
PMNs Crescents
56
What are the characteristics of hereditary nephritis (Alport syndrome)?
57
What are the pathologic characteristics of chronic hypertensive glomerulopathy?

Renal and Endocrine (46 decks)

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