Bioavailability and Clearance III + IV Flashcards
1
Q
Beta blockers
A
-lower QH
-lower cardiac output
2
Q
incressing CL
A
dec AUCiv
3
Q
factors effecting F of low Eh drug
A
-none
4
Q
factors affecting F in HIGH EH drug
A
-QH
-fu
-CLint
5
Q
increasing CLint will
A
decrease F of high EH drug
6
Q
Factors affecting AUC
A
factors affecting CL
7
Q
CL and AUCiv move in
A
opposite directions
8
Q
factors affecting AUCiv of low EH drug
A
-fu
-CLint
9
Q
factors affecting AUCiv of high EH drug
A
-Qh
10
Q
Oral clearance of low and high EH drugs
A
CL/F = fu x CLint
11
Q
factors affecting AUCpo
A
-fu
-CLint
in both high and low EH drugs
12
Q
CL and AUCpo move in
A
opposite directions
13
Q
Weak base is ionized at
A
low pH
14
Q
ionization of drug (polar, strong acids and bases)
A
-low reabsorption
-lower renal CL
15
Q
unionized drug (weak acids and bases)
A
-higher reabsorption
-low renal CL
