Hippocampus and Memory

Question 1

Hebb’s “Cell Assembly” theory

Answer 1

• To the extent that a memory depends on each individual connection, it is localized
• To the extent that recalling a full memory depends on reactivating the entire network, it is distributed

Question 2

remember the graph for multiple memory systems (just for fun)

Answer 2

slide 6

Question 3

components of hippocampal memory system (or medial temporal lobe)

Answer 3

parahippocampal cortex
entorhinal cortex
perirhinal cortex
hippocampus

Question 4

components of hippocampus

Answer 4

CA fields
dentate gyrus
subiculum

Question 5

where and what pathways

Answer 5

slide 13

Question 6

role of each components of MTL

Answer 6

perirhinal: nonspatial cortical input
parahippocampal: spatial (context) cortical input
entorhinal: integration separately - lateral to perirhinal cortex and medial to parahippocampal cortex
hippocampus: integration

Question 7

experiments showing damage to hippocampus and MTL influence memory

Answer 7

drawing a picture from copying and memory

influence on anterograde amnesia and temporally-graded retrograde amnesia

slide 22

Question 8

systems consolidation

Answer 8

explaining temporally-graded retrograde amnesia?

Question 9

describe the delayed Non-match to sample task (DNMS)

Answer 9

a typical recognition memory task for monkeys

delay-dependent recognition memory impairment for objects encountered only once (slide 40)

Question 10

describe probe test

Answer 10

premise pair training vs ordered representation

rats with damage to fornix and parhippocampal region show impairment to relational probe pair

Question 11

experiment shows that rats with hippocampal damage learned slowly, but eventually learned

Answer 11

Morris water maze

switch to new positions (novel probe tests), latency increases for rats with hippocampal damage